Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis
Abstract The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil, cremophor RH 40 as surfactant and Polyethylene Glycol 400 a...
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Academia Brasileira de Ciências
2021-12-01
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Series: | Anais da Academia Brasileira de Ciências |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800603&tlng=en |
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author | MUHAMMAD NAEEM TANIYA IQBAL ZARQA NAWAZ SAJJAD HUSSAIN |
author_facet | MUHAMMAD NAEEM TANIYA IQBAL ZARQA NAWAZ SAJJAD HUSSAIN |
author_sort | MUHAMMAD NAEEM |
collection | DOAJ |
description | Abstract The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil, cremophor RH 40 as surfactant and Polyethylene Glycol 400 as co-surfactant. Pseudoternary phase diagrams were constructed to find out microemulsion region. Independent variables (oil, Smix and water) concentration was used at high (+1) and low levels (-1) that would generate 17 different combinations of microemulsions. Microemulsions were characterized, optimized and evaluated. pH, viscosity, conductivities, refractive index, droplet size and poly-dispersity-index was investigated. Prepared microemulsions were oil in water, thermodynamically stable, isotropic, transparent, deflocculated and within narrow range of size. Mathematical equations and response surface plots related the independent and dependent variables. Optimum microemulsion ME6 was further incorporated with carbomer 940 gel base to produce microemulsion based gel. ME6 and its gel showed significant difference (p<0.05) from control gel. Stability studies showed prepared MEBG of celecoxib was stable during storage period. Skin irritation studies found the gel was safe and non-irritating to skin. Anti-inflammatory studies showed significant difference (p<0.05) compared to control gel. Thus, the therapeutic system was successfully developed and optimized using Box Behnken statistical design. |
first_indexed | 2024-04-11T15:28:56Z |
format | Article |
id | doaj.art-4e836b2af8a54ed89d4f5922bcf592ef |
institution | Directory Open Access Journal |
issn | 1678-2690 |
language | English |
last_indexed | 2024-04-11T15:28:56Z |
publishDate | 2021-12-01 |
publisher | Academia Brasileira de Ciências |
record_format | Article |
series | Anais da Academia Brasileira de Ciências |
spelling | doaj.art-4e836b2af8a54ed89d4f5922bcf592ef2022-12-22T04:16:11ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902021-12-0193suppl 410.1590/0001-3765202120201561Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritisMUHAMMAD NAEEMhttps://orcid.org/0000-0003-3368-8270TANIYA IQBALhttps://orcid.org/0000-0003-1061-528XZARQA NAWAZhttps://orcid.org/0000-0003-4251-3069SAJJAD HUSSAINhttps://orcid.org/0000-0003-0635-1461Abstract The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil, cremophor RH 40 as surfactant and Polyethylene Glycol 400 as co-surfactant. Pseudoternary phase diagrams were constructed to find out microemulsion region. Independent variables (oil, Smix and water) concentration was used at high (+1) and low levels (-1) that would generate 17 different combinations of microemulsions. Microemulsions were characterized, optimized and evaluated. pH, viscosity, conductivities, refractive index, droplet size and poly-dispersity-index was investigated. Prepared microemulsions were oil in water, thermodynamically stable, isotropic, transparent, deflocculated and within narrow range of size. Mathematical equations and response surface plots related the independent and dependent variables. Optimum microemulsion ME6 was further incorporated with carbomer 940 gel base to produce microemulsion based gel. ME6 and its gel showed significant difference (p<0.05) from control gel. Stability studies showed prepared MEBG of celecoxib was stable during storage period. Skin irritation studies found the gel was safe and non-irritating to skin. Anti-inflammatory studies showed significant difference (p<0.05) compared to control gel. Thus, the therapeutic system was successfully developed and optimized using Box Behnken statistical design.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800603&tlng=enAnti-inflammatory studiesCelecoxibfranz diffusion cellmicroemulsiontransdermal therapeutic system |
spellingShingle | MUHAMMAD NAEEM TANIYA IQBAL ZARQA NAWAZ SAJJAD HUSSAIN Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis Anais da Academia Brasileira de Ciências Anti-inflammatory studies Celecoxib franz diffusion cell microemulsion transdermal therapeutic system |
title | Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
title_full | Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
title_fullStr | Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
title_full_unstemmed | Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
title_short | Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
title_sort | preparation optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis |
topic | Anti-inflammatory studies Celecoxib franz diffusion cell microemulsion transdermal therapeutic system |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800603&tlng=en |
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