Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases
Objective: To analyze the pathological types, clinical characteristics and outcomes of human immunodeficiency virus (HIV)-infected patients with chronic kidney diseases (CKD). Methods: Thirty-two cases of HIV infection combined with CKD who underwent ultrasound guided renal biopsy in Shanghai Public...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Diagnostics Concepts & Practice
2022-08-01
|
| Series: | Zhenduanxue lilun yu shijian |
| Subjects: | |
| Online Access: | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1667814275228-583017469.pdf |
| _version_ | 1797975583347441664 |
|---|---|
| author | SHI Xia, MA Xin, WANG Zhenyan, ZHANG Hui, LIU Shaojun |
| author_facet | SHI Xia, MA Xin, WANG Zhenyan, ZHANG Hui, LIU Shaojun |
| author_sort | SHI Xia, MA Xin, WANG Zhenyan, ZHANG Hui, LIU Shaojun |
| collection | DOAJ |
| description | Objective: To analyze the pathological types, clinical characteristics and outcomes of human immunodeficiency virus (HIV)-infected patients with chronic kidney diseases (CKD). Methods: Thirty-two cases of HIV infection combined with CKD who underwent ultrasound guided renal biopsy in Shanghai Public Health Clinical Center from June 2016 to April 2021 were enrolled. Pathological types, clinical conditions and outcomes were all analyzed. Results: Among the 32 patients, there were 28 male and 4 female, with an average age of (43.5±12.3) years. The CD4+T lymphocyte count was (425.9±240.4) cells/μL. Twenty-six patients (81.3%) had been treated with antiretroviral therapy before renal puncture biopsy, and the median treatment time was 24 (1, 72) months. Among the pathological types, membranous nephropathy (8 cases, 25.0%) and IgA nephropathy (6 cases, 18.8%) accounted for the most types, followed by diabetic nephropathy (5 cases, 15.6%). No classical HIV-related nephropathy was found. During the follow-up period of 3 months to 5 years, the remission rate of renal disease reached 84.4% (13 complete remissions, 14 partial remissions), and the unresponsive rate was 9.4% (3 cases, including 1 case of lupus like immune complex mediated proliferative glomerulonephritis, 1 case of diabetes nephropathy, and 1 case of hypertensive nephropathy). The mortality rate was 6.3%(2 cases, all minor lesions). Conclusions: This study shows that the pathological types of HIV infected patients with CKD are various. Membranous nephropathy is predominant pathological type, and followed by IgA nephropathy and diabetes nephropathy, but classical HIV related nephropathy is not common. According to the pathological results of renal biopsy, renal disease related treatment based on antiretroviral therapy can alleviate renal disease or delay the progression of renal disease, but the prognosis of patients with minimal change nephropathy may be poor. |
| first_indexed | 2024-04-11T04:37:52Z |
| format | Article |
| id | doaj.art-4e847dc754e84a0cb35ace8981b8342a |
| institution | Directory Open Access Journal |
| issn | 1671-2870 |
| language | zho |
| last_indexed | 2024-04-11T04:37:52Z |
| publishDate | 2022-08-01 |
| publisher | Editorial Office of Journal of Diagnostics Concepts & Practice |
| record_format | Article |
| series | Zhenduanxue lilun yu shijian |
| spelling | doaj.art-4e847dc754e84a0cb35ace8981b8342a2022-12-28T08:51:23ZzhoEditorial Office of Journal of Diagnostics Concepts & PracticeZhenduanxue lilun yu shijian1671-28702022-08-01210443744310.16150/j.1671-2870.2022.04.004Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseasesSHI Xia, MA Xin, WANG Zhenyan, ZHANG Hui, LIU Shaojun01. 1a. Department of Ultrasound Medicine, 1b. Department of Infectious Disease, Shanghai Public Health Clinical Center, Shanghai 201508, China;2. Department of Ultrasound, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China;3. Department of Nephrology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China;4. Department of Clinical Medicine, Medical College of Nantong University, Jiangsu Nantong 226019, ChinaObjective: To analyze the pathological types, clinical characteristics and outcomes of human immunodeficiency virus (HIV)-infected patients with chronic kidney diseases (CKD). Methods: Thirty-two cases of HIV infection combined with CKD who underwent ultrasound guided renal biopsy in Shanghai Public Health Clinical Center from June 2016 to April 2021 were enrolled. Pathological types, clinical conditions and outcomes were all analyzed. Results: Among the 32 patients, there were 28 male and 4 female, with an average age of (43.5±12.3) years. The CD4+T lymphocyte count was (425.9±240.4) cells/μL. Twenty-six patients (81.3%) had been treated with antiretroviral therapy before renal puncture biopsy, and the median treatment time was 24 (1, 72) months. Among the pathological types, membranous nephropathy (8 cases, 25.0%) and IgA nephropathy (6 cases, 18.8%) accounted for the most types, followed by diabetic nephropathy (5 cases, 15.6%). No classical HIV-related nephropathy was found. During the follow-up period of 3 months to 5 years, the remission rate of renal disease reached 84.4% (13 complete remissions, 14 partial remissions), and the unresponsive rate was 9.4% (3 cases, including 1 case of lupus like immune complex mediated proliferative glomerulonephritis, 1 case of diabetes nephropathy, and 1 case of hypertensive nephropathy). The mortality rate was 6.3%(2 cases, all minor lesions). Conclusions: This study shows that the pathological types of HIV infected patients with CKD are various. Membranous nephropathy is predominant pathological type, and followed by IgA nephropathy and diabetes nephropathy, but classical HIV related nephropathy is not common. According to the pathological results of renal biopsy, renal disease related treatment based on antiretroviral therapy can alleviate renal disease or delay the progression of renal disease, but the prognosis of patients with minimal change nephropathy may be poor.http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1667814275228-583017469.pdf|human immunodeficiency virus|nephropathy|kidney biopsy|anti-retroviral therapy |
| spellingShingle | SHI Xia, MA Xin, WANG Zhenyan, ZHANG Hui, LIU Shaojun Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases Zhenduanxue lilun yu shijian |human immunodeficiency virus|nephropathy|kidney biopsy|anti-retroviral therapy |
| title | Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| title_full | Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| title_fullStr | Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| title_full_unstemmed | Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| title_short | Analysis on the clinicopathological characteristics and follow-up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| title_sort | analysis on the clinicopathological characteristics and follow up of 32 patients with human immunodeficiency virus infection and chronic kidney diseases |
| topic | |human immunodeficiency virus|nephropathy|kidney biopsy|anti-retroviral therapy |
| url | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1667814275228-583017469.pdf |
| work_keys_str_mv | AT shixiamaxinwangzhenyanzhanghuiliushaojun analysisontheclinicopathologicalcharacteristicsandfollowupof32patientswithhumanimmunodeficiencyvirusinfectionandchronickidneydiseases |