Integrated molecular landscape of Parkinson’s disease
Molecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Net...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-04-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-017-0015-3 |
| _version_ | 1797430114267430912 |
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| author | C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans |
| author_facet | C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans |
| author_sort | C. J. H. M. Klemann |
| collection | DOAJ |
| description | Molecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Netherlands, Germany and the USA have mapped the interactions of proteins that are encoded by genes associated with both familial and sporadic forms of PD. They identify the oxidative stress response, lysosomal function, endoplasmic reticulum stress response and immune response activation as the main mechanisms leading to the death of dopaminergic neurons. Lipid signaling is implicated in all four of these processes and the authors find a link between the levels of particular lipids and lipoproteins and the risk of PD. These findings suggest that compounds that regulate lipid or lipoprotein levels offer a potential new treatment strategy for PD. |
| first_indexed | 2024-03-09T09:23:56Z |
| format | Article |
| id | doaj.art-4e860d8b3bd7468199c2d2e11594e038 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T09:23:56Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-4e860d8b3bd7468199c2d2e11594e0382023-12-02T06:48:26ZengNature Portfolionpj Parkinson's Disease2373-80572017-04-01311710.1038/s41531-017-0015-3Integrated molecular landscape of Parkinson’s diseaseC. J. H. M. Klemann0G. J. M. Martens1M. Sharma2M. B. Martens3O. Isacson4T. Gasser5J. E. Visser6G. Poelmans7Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud UniversityDepartment of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud UniversityCentre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of TübingenDepartment of Neuroinformatics, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityNeuroregeneration Research Institute, McLean Hospital/Harvard Medical SchoolDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE)Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud UniversityDepartment of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud UniversityMolecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Netherlands, Germany and the USA have mapped the interactions of proteins that are encoded by genes associated with both familial and sporadic forms of PD. They identify the oxidative stress response, lysosomal function, endoplasmic reticulum stress response and immune response activation as the main mechanisms leading to the death of dopaminergic neurons. Lipid signaling is implicated in all four of these processes and the authors find a link between the levels of particular lipids and lipoproteins and the risk of PD. These findings suggest that compounds that regulate lipid or lipoprotein levels offer a potential new treatment strategy for PD.https://doi.org/10.1038/s41531-017-0015-3 |
| spellingShingle | C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans Integrated molecular landscape of Parkinson’s disease npj Parkinson's Disease |
| title | Integrated molecular landscape of Parkinson’s disease |
| title_full | Integrated molecular landscape of Parkinson’s disease |
| title_fullStr | Integrated molecular landscape of Parkinson’s disease |
| title_full_unstemmed | Integrated molecular landscape of Parkinson’s disease |
| title_short | Integrated molecular landscape of Parkinson’s disease |
| title_sort | integrated molecular landscape of parkinson s disease |
| url | https://doi.org/10.1038/s41531-017-0015-3 |
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