Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study
Abstract Background Many studies have shown that both elevated serum uric acid (SUA) levels and hyperhomocysteinemia are risk factors for atherosclerosis. However, the relationship between the two has not been thoroughly investigated. Objective This study aimed to explore the possible link between S...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-12-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03586-0 |
| _version_ | 1797398199710777344 |
|---|---|
| author | Jiangsha Wang Jie Zhou Zhengping Shao Xi Chen Zhenhai Yu Wenyan Zhao |
| author_facet | Jiangsha Wang Jie Zhou Zhengping Shao Xi Chen Zhenhai Yu Wenyan Zhao |
| author_sort | Jiangsha Wang |
| collection | DOAJ |
| description | Abstract Background Many studies have shown that both elevated serum uric acid (SUA) levels and hyperhomocysteinemia are risk factors for atherosclerosis. However, the relationship between the two has not been thoroughly investigated. Objective This study aimed to explore the possible link between SUA levels and homocysteine (Hcy) levels. Methods In this cross-sectional study, 17,692 adults aged > 19 years in National Health and Nutrition Examination Survey from 1999 to 2006 were analyzed. Multivariable linear regression analysis was performed to assess the association between SUA and Hcy levels. In addition, smooth curve fitting (penalized spline method) and threshold effect analysis were performed. Results Multivariable linear analysis showed that Hcy levels increased by 0.48 µmol/L (β = 0.48, 95%CI: 0.43–0.53) for every 1 mg/dL increase in SUA levels. We found a nonlinear relationship between SUA and Hcy levels. The results of threshold effect analysis showed that the inflection point for SUA levels was 7.1 mg/dL (β = 0.29, 95% CI: 0.23–0.36 and β = 1.05, 95% CI: 0.67–1.43 on the left and right sides of the inflection point, respectively). The p-values was less than 0.001 when using the log likelihood ratio test. This nonlinear relationship was also found in both sexes. The inflection point for SUA levels was 5.4 mg/dL in males and 7.3 mg/dL in females, respectively. Conclusions This cross-sectional study showed that the SUA levels were positively correlated with Hcy levels. And we found a nonlinear relationship between SUA and Hcy levels. |
| first_indexed | 2024-03-09T01:21:22Z |
| format | Article |
| id | doaj.art-4e86522a8dc846b59a64c406fb8c0a96 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-09T01:21:22Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4e86522a8dc846b59a64c406fb8c0a962023-12-10T12:06:26ZengBMCBMC Cardiovascular Disorders1471-22612023-12-0123111110.1186/s12872-023-03586-0Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional studyJiangsha Wang0Jie Zhou1Zhengping Shao2Xi Chen3Zhenhai Yu4Wenyan Zhao5Department of Cardiology, Jiande Hospital of Integrated Traditional Chinese and Western MedicineCenter for General Practice Medicine, General Practice and Health Management Center, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Department of Cardiology, Jiande Hospital of Integrated Traditional Chinese and Western MedicineCenter for General Practice Medicine, General Practice and Health Management Center, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Department of Neurosurgery, De Qing People’s HospitalCenter for General Practice Medicine, General Practice and Health Management Center, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Abstract Background Many studies have shown that both elevated serum uric acid (SUA) levels and hyperhomocysteinemia are risk factors for atherosclerosis. However, the relationship between the two has not been thoroughly investigated. Objective This study aimed to explore the possible link between SUA levels and homocysteine (Hcy) levels. Methods In this cross-sectional study, 17,692 adults aged > 19 years in National Health and Nutrition Examination Survey from 1999 to 2006 were analyzed. Multivariable linear regression analysis was performed to assess the association between SUA and Hcy levels. In addition, smooth curve fitting (penalized spline method) and threshold effect analysis were performed. Results Multivariable linear analysis showed that Hcy levels increased by 0.48 µmol/L (β = 0.48, 95%CI: 0.43–0.53) for every 1 mg/dL increase in SUA levels. We found a nonlinear relationship between SUA and Hcy levels. The results of threshold effect analysis showed that the inflection point for SUA levels was 7.1 mg/dL (β = 0.29, 95% CI: 0.23–0.36 and β = 1.05, 95% CI: 0.67–1.43 on the left and right sides of the inflection point, respectively). The p-values was less than 0.001 when using the log likelihood ratio test. This nonlinear relationship was also found in both sexes. The inflection point for SUA levels was 5.4 mg/dL in males and 7.3 mg/dL in females, respectively. Conclusions This cross-sectional study showed that the SUA levels were positively correlated with Hcy levels. And we found a nonlinear relationship between SUA and Hcy levels.https://doi.org/10.1186/s12872-023-03586-0Uric acidHomocysteineAdultsNHANES |
| spellingShingle | Jiangsha Wang Jie Zhou Zhengping Shao Xi Chen Zhenhai Yu Wenyan Zhao Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study BMC Cardiovascular Disorders Uric acid Homocysteine Adults NHANES |
| title | Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study |
| title_full | Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study |
| title_fullStr | Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study |
| title_full_unstemmed | Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study |
| title_short | Association between serum uric acid and homocysteine levels among adults in the United States: a cross-sectional study |
| title_sort | association between serum uric acid and homocysteine levels among adults in the united states a cross sectional study |
| topic | Uric acid Homocysteine Adults NHANES |
| url | https://doi.org/10.1186/s12872-023-03586-0 |
| work_keys_str_mv | AT jiangshawang associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy AT jiezhou associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy AT zhengpingshao associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy AT xichen associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy AT zhenhaiyu associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy AT wenyanzhao associationbetweenserumuricacidandhomocysteinelevelsamongadultsintheunitedstatesacrosssectionalstudy |