Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India
Introduction: The hallmark of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is high infectivity, pre symptomatic transmission and asymptomatic prevalence which could result in high cumulative numbers of infections, hospitalisations, and deaths. Kerala was the first stat...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15154/48703_CE[Ra1]_F(SL)_PF1(AG_OM)_PFA(KM_AnK)%20PB(AG_AnK)_PN(KM).pdf |
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| author | Aboobacker Mohamed Rafi Manglin Monica Lisa Joseph Tomy Ronnie Thomas Chithra Valsan UG Unnikrishnan Susheela J Innah Praveenlal Kuttichira |
| author_facet | Aboobacker Mohamed Rafi Manglin Monica Lisa Joseph Tomy Ronnie Thomas Chithra Valsan UG Unnikrishnan Susheela J Innah Praveenlal Kuttichira |
| author_sort | Aboobacker Mohamed Rafi |
| collection | DOAJ |
| description | Introduction: The hallmark of Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection is high
infectivity, pre symptomatic transmission and asymptomatic
prevalence which could result in high cumulative numbers
of infections, hospitalisations, and deaths. Kerala was the
first state to confirm community transmission in July 2020.
Healthcare Workers (HCWs) being in the forefront in the war
against Coronavirus Disease-2019 (COVID-19) are more prone
to acquire the infection and could possibly be asymptomatic
sources for cluster formation. Knowing the development of
immunity as shown by the presence of anti COV-2 antibodies in
the population contributes to the epidemiological understanding
of the disease.
Aim: To determine the pattern of seropositivity of SARS-CoV-2
among the HCWs at Jubilee Mission Medical College and
Research Institute, Thrissur, Kerala, India, six months after
revoking the lockdown.
Materials and Methods: This cross-sectional study was carried
out among 423 HCWs of the medical college from September
5th to December 15th, 2020. Multistage sampling was done
with the hospital block as the first stage and departments
as the second stage. Blood sample was collected and Anti
SARS COV-2 IgG antibody testing which targets the Spike
Protein 1 (SP1) was done using the vitros chemiluminescence
platform (Orthoclinical diagnostics, USA). For the summary
of demographic characteristics, continuous variables were
summarised as mean values and Standard Deviation (SD) while
categorical variables were summarised as proportions. The
χ2
test was used for comparing the epidemiological features
between positive and negative cases. Chi-square test for trend
analysis was done for exploring the relationship of the degree
of severity with test positivity. All analyses were conducted
using Statistical Package for the Social Sciences (SPSS)
version 25.0.
Results: Jubilee Mission Medical College had 2785 working
staff at the time of study. A total of 423 staff consented and
their samples were tested. Thirty seven staff members tested
positive for COVID-19 antibody, yielding an overall prevalence
of 8.75% (95% CI, 6.23-11.86). A 86.5% (32/37) of them were
having a history of COVID-19 Antigen/Reverse Transcriptase
Polymerase Chain Reaction (RT-PCR) Positivity. A statistically
significant linear trend (p-value=0.00001) was observed, between
seropositivity and the degree of severity of COVID-19. Among
the various factors which increase the risk of seroconversion,
history of undergoing quarantine (p-value <0.001), contact with
a confirmed case (p-value=0.002), contact with a caregiver for
COVID-19 (p-value=0.001) and history of upper respiratory
symptoms (p-value=0.001), were found to be significantly
associated with positive serology.
Conclusion: The pattern of seropositivity across the different
category of HCWs observed in the present study showed a higher
prevalence among nurses. Being an educational institution, it
was obligatory to train all the elements of care delivery to the
future generation of HCWs. Acquiring experience from a small but
relevant sample was expected to facilitate larger community study
envisaged in peripheral areas Jubilee Mission Hospital served. |
| first_indexed | 2024-12-16T08:27:43Z |
| format | Article |
| id | doaj.art-4e86693e93df4f7781ffbae97ca6c610 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T08:27:43Z |
| publishDate | 2021-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-4e86693e93df4f7781ffbae97ca6c6102022-12-21T22:37:57ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-07-011507131710.7860/JCDR/2021/48703.15154Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, IndiaAboobacker Mohamed Rafi0Manglin Monica Lisa Joseph Tomy1Ronnie Thomas2Chithra Valsan3UG Unnikrishnan4Susheela J Innah5Praveenlal Kuttichira6Assistant Professor, Department of Transfusion Medicine and Clinical Lab, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaJunior Resident, Department of Transfusion Medicine and Clinical Lab, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaAssistant Professor, Department of Community Medicine, Government Medical College, Kottayam, Kerala, IndiaProfessor, Department of Microbiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaLecturer, Department of Biostatistics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaProfessor and Head, Department of Transfusion Medicine and Clinical Lab, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaProfessor and Principal, Department of Psychiatry, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaIntroduction: The hallmark of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is high infectivity, pre symptomatic transmission and asymptomatic prevalence which could result in high cumulative numbers of infections, hospitalisations, and deaths. Kerala was the first state to confirm community transmission in July 2020. Healthcare Workers (HCWs) being in the forefront in the war against Coronavirus Disease-2019 (COVID-19) are more prone to acquire the infection and could possibly be asymptomatic sources for cluster formation. Knowing the development of immunity as shown by the presence of anti COV-2 antibodies in the population contributes to the epidemiological understanding of the disease. Aim: To determine the pattern of seropositivity of SARS-CoV-2 among the HCWs at Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India, six months after revoking the lockdown. Materials and Methods: This cross-sectional study was carried out among 423 HCWs of the medical college from September 5th to December 15th, 2020. Multistage sampling was done with the hospital block as the first stage and departments as the second stage. Blood sample was collected and Anti SARS COV-2 IgG antibody testing which targets the Spike Protein 1 (SP1) was done using the vitros chemiluminescence platform (Orthoclinical diagnostics, USA). For the summary of demographic characteristics, continuous variables were summarised as mean values and Standard Deviation (SD) while categorical variables were summarised as proportions. The χ2 test was used for comparing the epidemiological features between positive and negative cases. Chi-square test for trend analysis was done for exploring the relationship of the degree of severity with test positivity. All analyses were conducted using Statistical Package for the Social Sciences (SPSS) version 25.0. Results: Jubilee Mission Medical College had 2785 working staff at the time of study. A total of 423 staff consented and their samples were tested. Thirty seven staff members tested positive for COVID-19 antibody, yielding an overall prevalence of 8.75% (95% CI, 6.23-11.86). A 86.5% (32/37) of them were having a history of COVID-19 Antigen/Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) Positivity. A statistically significant linear trend (p-value=0.00001) was observed, between seropositivity and the degree of severity of COVID-19. Among the various factors which increase the risk of seroconversion, history of undergoing quarantine (p-value <0.001), contact with a confirmed case (p-value=0.002), contact with a caregiver for COVID-19 (p-value=0.001) and history of upper respiratory symptoms (p-value=0.001), were found to be significantly associated with positive serology. Conclusion: The pattern of seropositivity across the different category of HCWs observed in the present study showed a higher prevalence among nurses. Being an educational institution, it was obligatory to train all the elements of care delivery to the future generation of HCWs. Acquiring experience from a small but relevant sample was expected to facilitate larger community study envisaged in peripheral areas Jubilee Mission Hospital served.https://jcdr.net/articles/PDF/15154/48703_CE[Ra1]_F(SL)_PF1(AG_OM)_PFA(KM_AnK)%20PB(AG_AnK)_PN(KM).pdfcoronavirus disease 2019pandemicseropositivityspike protein |
| spellingShingle | Aboobacker Mohamed Rafi Manglin Monica Lisa Joseph Tomy Ronnie Thomas Chithra Valsan UG Unnikrishnan Susheela J Innah Praveenlal Kuttichira Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India Journal of Clinical and Diagnostic Research coronavirus disease 2019 pandemic seropositivity spike protein |
| title | Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India |
| title_full | Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India |
| title_fullStr | Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India |
| title_full_unstemmed | Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India |
| title_short | Serosurveillance of SARS-CoV-2 among the Healthcare Workers of a Tertiary Care Teaching Institution during the Post Lockdown Phase in Central Kerala, India |
| title_sort | serosurveillance of sars cov 2 among the healthcare workers of a tertiary care teaching institution during the post lockdown phase in central kerala india |
| topic | coronavirus disease 2019 pandemic seropositivity spike protein |
| url | https://jcdr.net/articles/PDF/15154/48703_CE[Ra1]_F(SL)_PF1(AG_OM)_PFA(KM_AnK)%20PB(AG_AnK)_PN(KM).pdf |
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