IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)

In a review of literature from the modern point of the mechanisms of observed during physiological and pathological pregnancy. Present and discuss the various hypotheses of gestation. In particular, shows evidence of local immunosuppressive role in the development of pregnancy. At the same time acti...

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Main Authors: D. D. Nefedovа, V. A. Lindе, M. A. Levkovich
Format: Article
Language:English
Published: State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation 2013-12-01
Series:Медицинский вестник Юга России
Subjects:
Online Access:https://www.medicalherald.ru/jour/article/view/130
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author D. D. Nefedovа
V. A. Lindе
M. A. Levkovich
author_facet D. D. Nefedovа
V. A. Lindе
M. A. Levkovich
author_sort D. D. Nefedovа
collection DOAJ
description In a review of literature from the modern point of the mechanisms of observed during physiological and pathological pregnancy. Present and discuss the various hypotheses of gestation. In particular, shows evidence of local immunosuppressive role in the development of pregnancy. At the same time actively involved antigens HLA class, natural killer cells, and pro-and antiinflammatory cytokines. In normal pregnancy, the cytokine balance towards the immunosuppressive Th-2 cytokines that inhibit the cellular immune response and stimulating steroids (progesterone, hCG) and the development of blocking antibodies. The role of apoptosis and T regulatory cells in the pathogenesis of complicated pregnancy. It is assumed that during pregnancy there is a unique interaction between the innate and adaptive immune mothers, the role of chief executives of the regulatory cells perform, asking for the innate immune response.
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spelling doaj.art-4e87cf4017e844d385a7b04467dff3fe2022-12-22T04:39:50ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762013-12-0104162110.21886/2219-8075-2013-4-16-21129IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)D. D. Nefedovа0V. A. Lindе1M. A. Levkovich2Rostov Scientific and Research Institute of Obstetrics and PediatricsRostov Scientific and Research Institute of Obstetrics and PediatricsRostov Scientific and Research Institute of Obstetrics and PediatricsIn a review of literature from the modern point of the mechanisms of observed during physiological and pathological pregnancy. Present and discuss the various hypotheses of gestation. In particular, shows evidence of local immunosuppressive role in the development of pregnancy. At the same time actively involved antigens HLA class, natural killer cells, and pro-and antiinflammatory cytokines. In normal pregnancy, the cytokine balance towards the immunosuppressive Th-2 cytokines that inhibit the cellular immune response and stimulating steroids (progesterone, hCG) and the development of blocking antibodies. The role of apoptosis and T regulatory cells in the pathogenesis of complicated pregnancy. It is assumed that during pregnancy there is a unique interaction between the innate and adaptive immune mothers, the role of chief executives of the regulatory cells perform, asking for the innate immune response.https://www.medicalherald.ru/jour/article/view/130pregnancycytokinesimmune system
spellingShingle D. D. Nefedovа
V. A. Lindе
M. A. Levkovich
IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
Медицинский вестник Юга России
pregnancy
cytokines
immune system
title IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
title_full IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
title_fullStr IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
title_full_unstemmed IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
title_short IMMUNOLOGICAL ASPECTS OF PREGNANCY (REVIEW)
title_sort immunological aspects of pregnancy review
topic pregnancy
cytokines
immune system
url https://www.medicalherald.ru/jour/article/view/130
work_keys_str_mv AT ddnefedova immunologicalaspectsofpregnancyreview
AT valinde immunologicalaspectsofpregnancyreview
AT malevkovich immunologicalaspectsofpregnancyreview