Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions
Background/Aim. Interpretation of cytological material obtained by fine needle aspiration (FNA) of salivary glands is one of the most challenging areas in cytopathology. FNA is performed easily, it is minimally invasive, inexpensive, fast, reliable and provides valuable information to clini...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501411018G.pdf |
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| author | Gajanin Radoslav Đurđević Dejan Knežević-Ušaj Slavica Eri Živka Ljubojević Vesna Karalić Marinko Risović Tatjana |
| author_facet | Gajanin Radoslav Đurđević Dejan Knežević-Ušaj Slavica Eri Živka Ljubojević Vesna Karalić Marinko Risović Tatjana |
| author_sort | Gajanin Radoslav |
| collection | DOAJ |
| description | Background/Aim. Interpretation of cytological material obtained by fine
needle aspiration (FNA) of salivary glands is one of the most challenging
areas in cytopathology. FNA is performed easily, it is minimally invasive,
inexpensive, fast, reliable and provides valuable information to clinicians
about the nature of the lesion and therapeutic modalities. Ex tempore
diagnosis, frozen section (FS) is a diagnostic tool that is essential in
determining the modalities of surgical treatment of lesions of the salivary
glands. Today this method is used in determining the status of resection
margins and infiltration of adjacent anatomical structures. The aim of this
study was to present our experiences in the application of FNA and FS in the
diagnosis of salivary gland lesions and to determine the sensitivity,
specificity, predictive value, and diagnostic reliability of these methods.
Methods. The study included 36 patients. In all the patients, cytological
analysis was done before surgery and histological analysis of the surgical
material. In 23 of the patients the FS diagnostics was done. Then we compared
FNA and FS findings with histopathological findings. Results. Correlation of
cytological and histological diagnosis showed sensitivity of 83.3%,
specificity 96.67%, positive predictive value 83.3%, negative predictive
value of 96.77% and diagnostic accuracy of 97.2%. Based on the relationship
between FS diagnosis and histopathological diagnosis, the sensitivity was
100%, specificity 96.67%, while positive predictive value and diagnostic
accuracy were 100% each. Conclusion. The study confirmed that FNA is a
sensitive, reliable diagnostic method for differentiation of lesions of the
salivary glands. In cases with no posibility to definite differentiation in
FNA samples, and with the need to assess the resection margins and invasion
of anatomical structures, it is recommended to use FS diagnostics. |
| first_indexed | 2024-12-13T20:29:41Z |
| format | Article |
| id | doaj.art-4e87de41435a4929a488a29ae650c184 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-13T20:29:41Z |
| publishDate | 2014-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-4e87de41435a4929a488a29ae650c1842022-12-21T23:32:27ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502014-01-0171111018102510.2298/VSP1411018G0042-84501411018GReliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesionsGajanin Radoslav0Đurđević Dejan1Knežević-Ušaj Slavica2Eri Živka3Ljubojević Vesna4Karalić Marinko5Risović Tatjana6University of Banja Luka, Clinical Centre Banja Luka, Faculty of Medicine, Banja Luka, Bosnia and HerzegovinaUniversity of Banja Luka, Clinical Centre Banja Luka, Faculty of Medicine, Banja Luka, Bosnia and HerzegovinaFaculty of Medicine, Institute of Oncology of Vojvodina, Department of Pathology, Novi SadFaculty of Medicine, Institute of Lung Disease, Department of Pathology, Novi SadUniversity of Banja Luka, Faculty of Medicine, Department of Histology and Embryology, Banja Luka, Bosnia and HerzegovinaUniversity of Banja Luka, Clinical Centre Banja Luka, Faculty of Medicine, Banja Luka, Bosnia and HerzegovinaUniversity of Banja Luka, Clinical Centre Banja Luka, Faculty of Medicine, Banja Luka, Bosnia and HerzegovinaBackground/Aim. Interpretation of cytological material obtained by fine needle aspiration (FNA) of salivary glands is one of the most challenging areas in cytopathology. FNA is performed easily, it is minimally invasive, inexpensive, fast, reliable and provides valuable information to clinicians about the nature of the lesion and therapeutic modalities. Ex tempore diagnosis, frozen section (FS) is a diagnostic tool that is essential in determining the modalities of surgical treatment of lesions of the salivary glands. Today this method is used in determining the status of resection margins and infiltration of adjacent anatomical structures. The aim of this study was to present our experiences in the application of FNA and FS in the diagnosis of salivary gland lesions and to determine the sensitivity, specificity, predictive value, and diagnostic reliability of these methods. Methods. The study included 36 patients. In all the patients, cytological analysis was done before surgery and histological analysis of the surgical material. In 23 of the patients the FS diagnostics was done. Then we compared FNA and FS findings with histopathological findings. Results. Correlation of cytological and histological diagnosis showed sensitivity of 83.3%, specificity 96.67%, positive predictive value 83.3%, negative predictive value of 96.77% and diagnostic accuracy of 97.2%. Based on the relationship between FS diagnosis and histopathological diagnosis, the sensitivity was 100%, specificity 96.67%, while positive predictive value and diagnostic accuracy were 100% each. Conclusion. The study confirmed that FNA is a sensitive, reliable diagnostic method for differentiation of lesions of the salivary glands. In cases with no posibility to definite differentiation in FNA samples, and with the need to assess the resection margins and invasion of anatomical structures, it is recommended to use FS diagnostics.http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501411018G.pdfbiopsy+ fine needlefrozen sectionssalivary glandshistological techniquessensitivity and specificity |
| spellingShingle | Gajanin Radoslav Đurđević Dejan Knežević-Ušaj Slavica Eri Živka Ljubojević Vesna Karalić Marinko Risović Tatjana Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions Vojnosanitetski Pregled biopsy+ fine needle frozen sections salivary glands histological techniques sensitivity and specificity |
| title | Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| title_full | Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| title_fullStr | Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| title_full_unstemmed | Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| title_short | Reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| title_sort | reliability of fine needle aspiration and ex tempore biopsy in the diagnosis of salivary glands lesions |
| topic | biopsy+ fine needle frozen sections salivary glands histological techniques sensitivity and specificity |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501411018G.pdf |
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