Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

Neonatal white matter injury (nWMI) is an increasingly common cause of cerebral palsy that results predominantly from hypoxic injury to progenitor cells including those of the oligodendrocyte lineage. Existing mouse models of nWMI utilize prolonged periods of hypoxia during the neonatal period, requ...

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Main Authors: Jens O Watzlawik, Robert J Kahoud, Ryan J O'Toole, Katherine A M White, Alyssa R Ogden, Meghan M Painter, Bharath Wootla, Louisa M Papke, Aleksandar Denic, Jill M Weimer, William A Carey, Moses Rodriguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4447462?pdf=render

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