Novel Epigenetic Eight-Gene Signature Predictive of Poor Prognosis and MSI-Like Phenotype in Human Metastatic Colorectal Carcinomas

Novel Epigenetic Eight-Gene Signature Predictive of Poor Prognosis and MSI-Like Phenotype in Human Metastatic Colorectal Carcinomas

Epigenetics is involved in tumor progression and drug resistance in human colorectal carcinoma (CRC). This study addressed the hypothesis that the DNA methylation profiling may predict the clinical behavior of metastatic CRCs (mCRCs). The global methylation profile of two human mCRC subgroups with s...

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Bibliographic Details
Main Authors: Valentina Condelli, Giovanni Calice, Alessandra Cassano, Michele Basso, Maria Grazia Rodriquenz, Angela Zupa, Francesca Maddalena, Fabiana Crispo, Michele Pietrafesa, Michele Aieta, Alessandro Sgambato, Giampaolo Tortora, Pietro Zoppoli, Matteo Landriscina
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
promoter methylation
colorectal carcinoma
gene signature
prognosis
MSI-like signature
CIMP status
Online Access:https://www.mdpi.com/2072-6694/13/1/158

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