Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador
Congenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (<i>Trypanosoma cruzi</i> infection) burdens in the Americas, yet pregnancy screening remains neglected. This p...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/4/233 |
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| author | Mary K. Lynn Marvin Stanley Rodriguez Aquino Pamela Michelle Cornejo Rivas Mufaro Kanyangarara Stella C. W. Self Berry A. Campbell Melissa S. Nolan |
| author_facet | Mary K. Lynn Marvin Stanley Rodriguez Aquino Pamela Michelle Cornejo Rivas Mufaro Kanyangarara Stella C. W. Self Berry A. Campbell Melissa S. Nolan |
| author_sort | Mary K. Lynn |
| collection | DOAJ |
| description | Congenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (<i>Trypanosoma cruzi</i> infection) burdens in the Americas, yet pregnancy screening remains neglected. This pilot investigation performed a maternal <i>T. cruzi</i> surveillance study in Western El Salvador among women presenting for labor and delivery. From 198 consented and enrolled pregnant women, 6% were <i>T. cruzi</i> positive by serology or molecular diagnosis. Half of the infants born to <i>T. cruzi</i>-positive women were admitted to the NICU for neonatal complications. Geospatial statistical clustering of cases was noted in the municipality of Jujutla. Older women and those knowing an infected relative or close friend were significantly more likely to test positive for <i>T. cruzi</i> infection at the time of parturition. In closing, maternal <i>T. cruzi</i> infections were significantly higher than national HIV or syphilis maternal rates, creating an urgent need to add <i>T. cruzi</i> to mandatory pregnancy screening programs. |
| first_indexed | 2024-03-11T04:27:59Z |
| format | Article |
| id | doaj.art-4e8d8fc75d5f4b97bfbe7893dd72e827 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-11T04:27:59Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-4e8d8fc75d5f4b97bfbe7893dd72e8272023-11-17T21:39:58ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-04-018423310.3390/tropicalmed8040233Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El SalvadorMary K. Lynn0Marvin Stanley Rodriguez Aquino1Pamela Michelle Cornejo Rivas2Mufaro Kanyangarara3Stella C. W. Self4Berry A. Campbell5Melissa S. Nolan6Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USAHealth Research and Development Center (CENSALUD), University of El Salvador, San Salvador, El SalvadorHealth Research and Development Center (CENSALUD), University of El Salvador, San Salvador, El SalvadorDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USADepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USADepartment of Obstetrics and Gynecology, Prisma Health, Columbia, SC 29203, USADepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USACongenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (<i>Trypanosoma cruzi</i> infection) burdens in the Americas, yet pregnancy screening remains neglected. This pilot investigation performed a maternal <i>T. cruzi</i> surveillance study in Western El Salvador among women presenting for labor and delivery. From 198 consented and enrolled pregnant women, 6% were <i>T. cruzi</i> positive by serology or molecular diagnosis. Half of the infants born to <i>T. cruzi</i>-positive women were admitted to the NICU for neonatal complications. Geospatial statistical clustering of cases was noted in the municipality of Jujutla. Older women and those knowing an infected relative or close friend were significantly more likely to test positive for <i>T. cruzi</i> infection at the time of parturition. In closing, maternal <i>T. cruzi</i> infections were significantly higher than national HIV or syphilis maternal rates, creating an urgent need to add <i>T. cruzi</i> to mandatory pregnancy screening programs.https://www.mdpi.com/2414-6366/8/4/233Chagas disease<i>Trypanosoma cruzi</i>vertical transmissioncongenitalEl Salvadorneglected tropical disease |
| spellingShingle | Mary K. Lynn Marvin Stanley Rodriguez Aquino Pamela Michelle Cornejo Rivas Mufaro Kanyangarara Stella C. W. Self Berry A. Campbell Melissa S. Nolan Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador Tropical Medicine and Infectious Disease Chagas disease <i>Trypanosoma cruzi</i> vertical transmission congenital El Salvador neglected tropical disease |
| title | Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador |
| title_full | Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador |
| title_fullStr | Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador |
| title_full_unstemmed | Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador |
| title_short | Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador |
| title_sort | chagas disease maternal seroprevalence and maternal fetal health outcomes in a parturition cohort in western el salvador |
| topic | Chagas disease <i>Trypanosoma cruzi</i> vertical transmission congenital El Salvador neglected tropical disease |
| url | https://www.mdpi.com/2414-6366/8/4/233 |
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