Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging
Detecting neuroplasticity in global brain circuits in vivo is key for understanding myriad processes such as memory, learning, and recovery from injury. Functional Magnetic Resonance Imaging (fMRI) is instrumental for such in vivo mappings, yet it typically relies on mapping changes in spatial exten...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920309319 |
| _version_ | 1818844809470672896 |
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| author | Rita Gil Francisca F. Fernandes Noam Shemesh |
| author_facet | Rita Gil Francisca F. Fernandes Noam Shemesh |
| author_sort | Rita Gil |
| collection | DOAJ |
| description | Detecting neuroplasticity in global brain circuits in vivo is key for understanding myriad processes such as memory, learning, and recovery from injury. Functional Magnetic Resonance Imaging (fMRI) is instrumental for such in vivo mappings, yet it typically relies on mapping changes in spatial extent of activation or via signal amplitude modulations, whose interpretation can be highly ambiguous. Importantly, a central aspect of neuroplasticity involves modulation of neural activity timing properties. We thus hypothesized that this temporal dimension could serve as a new marker for neuroplasticity. To detect fMRI signals more associated with the underlying neural dynamics, we developed an ultrafast fMRI (ufMRI) approach facilitating high spatiotemporal sensitivity and resolution in distributed neural pathways. When neuroplasticity was induced in the mouse visual pathway via dark rearing, ufMRI indeed mapped temporal modulations in the entire visual pathway. Our findings therefore suggest a new dimension for exploring neuroplasticity in vivo. |
| first_indexed | 2024-12-19T05:19:40Z |
| format | Article |
| id | doaj.art-4e8db4a7da324cde9a9b15c226ed7e50 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-19T05:19:40Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-4e8db4a7da324cde9a9b15c226ed7e502022-12-21T20:34:33ZengElsevierNeuroImage1095-95722021-01-01225117446Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imagingRita Gil0Francisca F. Fernandes1Noam Shemesh2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, PortugalChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, PortugalCorresponding author.; Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, PortugalDetecting neuroplasticity in global brain circuits in vivo is key for understanding myriad processes such as memory, learning, and recovery from injury. Functional Magnetic Resonance Imaging (fMRI) is instrumental for such in vivo mappings, yet it typically relies on mapping changes in spatial extent of activation or via signal amplitude modulations, whose interpretation can be highly ambiguous. Importantly, a central aspect of neuroplasticity involves modulation of neural activity timing properties. We thus hypothesized that this temporal dimension could serve as a new marker for neuroplasticity. To detect fMRI signals more associated with the underlying neural dynamics, we developed an ultrafast fMRI (ufMRI) approach facilitating high spatiotemporal sensitivity and resolution in distributed neural pathways. When neuroplasticity was induced in the mouse visual pathway via dark rearing, ufMRI indeed mapped temporal modulations in the entire visual pathway. Our findings therefore suggest a new dimension for exploring neuroplasticity in vivo.http://www.sciencedirect.com/science/article/pii/S1053811920309319fMRIUltrafast fMRIPlasticityVisual systemLine scanning |
| spellingShingle | Rita Gil Francisca F. Fernandes Noam Shemesh Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging NeuroImage fMRI Ultrafast fMRI Plasticity Visual system Line scanning |
| title | Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| title_full | Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| title_fullStr | Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| title_full_unstemmed | Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| title_short | Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| title_sort | neuroplasticity driven timing modulations revealed by ultrafast functional magnetic resonance imaging |
| topic | fMRI Ultrafast fMRI Plasticity Visual system Line scanning |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920309319 |
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