A Bacterial Quorum Sensing Regulated Protease Inhibits Host Immune Responses by Cleaving Death Domains of Innate Immune Adaptors

A Bacterial Quorum Sensing Regulated Protease Inhibits Host Immune Responses by Cleaving Death Domains of Innate Immune Adaptors

Abstract Innate immune adaptor proteins are critical components of the innate immune system that propagate pro‐inflammatory responses from their upstream receptors, and lead to pathogen clearance from the host. Bacterial pathogens have developed strategies to survive inside host cells without trigge...

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Bibliographic Details
Main Authors: Xiangke Duan, Zhao Zhi Boo, Song Lin Chua, Kelvin Han Chung Chong, Ziqi Long, Renliang Yang, Yachun Zhou, Baptiste Janela, Sanjay Haresh Chotirmall, Florent Ginhoux, Qinghua Hu, Bin Wu, Liang Yang
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
host‐microbe interaction
innate immune adaptor MyD88
protease
Pseudomonas aeruginosa
quorum sensing
Online Access:https://doi.org/10.1002/advs.202304891

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