Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective antagonists might restore dopaminergic hypofunction, thus representing a potenti...

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Main Authors: Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Psychiatry
Subjects:
emotional processing
dopamine
fMRI
D3 receptor
addiction
alcohol
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.998844/full

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