The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives
Sabrina Bimonte,1,* Marco Cascella,1,* Vincenzo Schiavone,2 Farrokh Mehrabi-Kermani,3 Arturo Cuomo1 1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori – IRCCS – “Fondazione G. Pascale”, Naples, Italy; 2Division of Anesthesia and Intensive Ca...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-09-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/the-roles-of-epigallocatechin-3-gallate-in-the-treatment-of-neuropathi-peer-reviewed-article-DDDT |
| _version_ | 1819266908439969792 |
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| author | Bimonte S Cascella M Schiavone V Mehrabi-Kermani F Cuomo A |
| author_facet | Bimonte S Cascella M Schiavone V Mehrabi-Kermani F Cuomo A |
| author_sort | Bimonte S |
| collection | DOAJ |
| description | Sabrina Bimonte,1,* Marco Cascella,1,* Vincenzo Schiavone,2 Farrokh Mehrabi-Kermani,3 Arturo Cuomo1 1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori – IRCCS – “Fondazione G. Pascale”, Naples, Italy; 2Division of Anesthesia and Intensive Care, Hospital “Pineta Grande”, Castel Volturno, Caserta, Italy; 3Division of Neurosurgery, Hospital “Pineta Grande”, Castel Volturno, Caserta, Italy *These authors contributed equally to this work Abstract: Neuropathic pain (NP) is a complex and chronic disease caused by lesions or defects of the somatosensory nervous system. The treatments normally used for managing NP usually lack efficacy. Several animal models of NP have been engineered in order to understand the molecular mechanisms underlying NP and to find alternative molecules to use as new therapeutic agents. Preclinical in vivo studies identified the epigallocatechin-3-gallate (EGCG), a main active component of green tea (Camellia sinensis), as a possible therapeutic molecule for NP treatment due to its anti-inflammatory and antioxidant properties. Interestingly, it has been shown that EGCG reduced bone cancer pain. The purpose of this article is to discuss the potential use of EGCG for control and treatment of NP, by reviewing the preclinical studies reported in the literature and by shedding light on the potential schemes based on EGCG’s application in clinical practices. Keywords: epigallocatechin-3-gallate, EGCG, natural compound, neuropathic pain, animal models of neuropathic pain, cancer bone pain |
| first_indexed | 2024-12-23T21:08:45Z |
| format | Article |
| id | doaj.art-4e8fecab8ac94250bf6988c16e2c1492 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-23T21:08:45Z |
| publishDate | 2017-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-4e8fecab8ac94250bf6988c16e2c14922022-12-21T17:31:08ZengDove Medical PressDrug Design, Development and Therapy1177-88812017-09-01Volume 112737274234715The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectivesBimonte SCascella MSchiavone VMehrabi-Kermani FCuomo ASabrina Bimonte,1,* Marco Cascella,1,* Vincenzo Schiavone,2 Farrokh Mehrabi-Kermani,3 Arturo Cuomo1 1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori – IRCCS – “Fondazione G. Pascale”, Naples, Italy; 2Division of Anesthesia and Intensive Care, Hospital “Pineta Grande”, Castel Volturno, Caserta, Italy; 3Division of Neurosurgery, Hospital “Pineta Grande”, Castel Volturno, Caserta, Italy *These authors contributed equally to this work Abstract: Neuropathic pain (NP) is a complex and chronic disease caused by lesions or defects of the somatosensory nervous system. The treatments normally used for managing NP usually lack efficacy. Several animal models of NP have been engineered in order to understand the molecular mechanisms underlying NP and to find alternative molecules to use as new therapeutic agents. Preclinical in vivo studies identified the epigallocatechin-3-gallate (EGCG), a main active component of green tea (Camellia sinensis), as a possible therapeutic molecule for NP treatment due to its anti-inflammatory and antioxidant properties. Interestingly, it has been shown that EGCG reduced bone cancer pain. The purpose of this article is to discuss the potential use of EGCG for control and treatment of NP, by reviewing the preclinical studies reported in the literature and by shedding light on the potential schemes based on EGCG’s application in clinical practices. Keywords: epigallocatechin-3-gallate, EGCG, natural compound, neuropathic pain, animal models of neuropathic pain, cancer bone painhttps://www.dovepress.com/the-roles-of-epigallocatechin-3-gallate-in-the-treatment-of-neuropathi-peer-reviewed-article-DDDT(-)-Epigallocatechin-3-gallate (EGCG)natural compoundneuropathic painanimal models of neuropathic paincancer bone pain. |
| spellingShingle | Bimonte S Cascella M Schiavone V Mehrabi-Kermani F Cuomo A The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives Drug Design, Development and Therapy (-)-Epigallocatechin-3-gallate (EGCG) natural compound neuropathic pain animal models of neuropathic pain cancer bone pain. |
| title | The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives |
| title_full | The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives |
| title_fullStr | The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives |
| title_full_unstemmed | The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives |
| title_short | The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives |
| title_sort | roles of epigallocatechin 3 gallate in the treatment of neuropathic pain an update on preclinical in vivo studies and future perspectives |
| topic | (-)-Epigallocatechin-3-gallate (EGCG) natural compound neuropathic pain animal models of neuropathic pain cancer bone pain. |
| url | https://www.dovepress.com/the-roles-of-epigallocatechin-3-gallate-in-the-treatment-of-neuropathi-peer-reviewed-article-DDDT |
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