Generation of a B2M homozygous knockout human somatic cell nuclear transfer-derived embryonic stem cell line using the CRISPR/Cas9 system

Generation of a B2M homozygous knockout human somatic cell nuclear transfer-derived embryonic stem cell line using the CRISPR/Cas9 system

Beta2-microglobulin (B2M) is a subunit of human leukocyte antigen class-I (HLA-I) heterodimer that mediates immune rejection through activation of cytotoxic T cells. B2M binding to HLA-I proteins is essential for functional HLA-I on the cell surface. Here, we generated a B2M homozygous knockout soma...

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Bibliographic Details
Main Authors: Ok-Hee Lee, Siyoung Lee, Miseon Park, Sohyeon Moon, Semi Hwang, Byeongseok Kim, C-Yoon Kim, Dong Ryul Lee, Sung Han Shim, Keun-Hong Park, Hyung Min Chung, Youngsok Choi
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121004906

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