Neurodegenerative disorders associated with genes of mitochondria
Abstract Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial dysfunction and development of several neurodegenerative disorders. Main text Recent structural and functional studies associated with mitoc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-03-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-021-00215-5 |
| _version_ | 1818352583744421888 |
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| author | Vaibhav S. Marde Prerna L. Tiwari Nitu L. Wankhede Brijesh G. Taksande Aman B. Upaganlawar Milind J. Umekar Mayur B. Kale |
| author_facet | Vaibhav S. Marde Prerna L. Tiwari Nitu L. Wankhede Brijesh G. Taksande Aman B. Upaganlawar Milind J. Umekar Mayur B. Kale |
| author_sort | Vaibhav S. Marde |
| collection | DOAJ |
| description | Abstract Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial dysfunction and development of several neurodegenerative disorders. Main text Recent structural and functional studies associated with mitochondrial genes have shown that mitochondrial abnormalities possibly lead to mitochondrial dysfunction. Several studies on animal models of neurodegenerative diseases and mitochondrial genes have provided compelling evidence that mitochondria is involved in the initiation as well as progression of diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and Friedreich ataxia (FA). Conclusion In this mini-review, we have discussed the different etiologic and pathogenesis connected with the mitochondrial dysfunction and relevant neurodegenerative diseases that underlie the dominant part of mitochondrial genes in the disease development and its progress. |
| first_indexed | 2024-12-13T18:55:57Z |
| format | Article |
| id | doaj.art-4e920affe7f1410b923a8b86d690d375 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-12-13T18:55:57Z |
| publishDate | 2021-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-4e920affe7f1410b923a8b86d690d3752022-12-21T23:34:48ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532021-03-01711810.1186/s43094-021-00215-5Neurodegenerative disorders associated with genes of mitochondriaVaibhav S. Marde0Prerna L. Tiwari1Nitu L. Wankhede2Brijesh G. Taksande3Aman B. Upaganlawar4Milind J. Umekar5Mayur B. Kale6National Institute of Pharmaceutical Education and ResearchSpringer Nature Technology and Publishing Solutions (SNTPS)Smt. Kishoritai Bhoyar College of PharmacySmt. Kishoritai Bhoyar College of PharmacySNJB’s Shriman Sureshdada Jain College of PharmacySmt. Kishoritai Bhoyar College of PharmacySmt. Kishoritai Bhoyar College of PharmacyAbstract Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial dysfunction and development of several neurodegenerative disorders. Main text Recent structural and functional studies associated with mitochondrial genes have shown that mitochondrial abnormalities possibly lead to mitochondrial dysfunction. Several studies on animal models of neurodegenerative diseases and mitochondrial genes have provided compelling evidence that mitochondria is involved in the initiation as well as progression of diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and Friedreich ataxia (FA). Conclusion In this mini-review, we have discussed the different etiologic and pathogenesis connected with the mitochondrial dysfunction and relevant neurodegenerative diseases that underlie the dominant part of mitochondrial genes in the disease development and its progress.https://doi.org/10.1186/s43094-021-00215-5Mitochondrial genesParkinson’s diseaseAlzheimer’s diseaseHuntington’s diseaseMutationFriedreich ataxia |
| spellingShingle | Vaibhav S. Marde Prerna L. Tiwari Nitu L. Wankhede Brijesh G. Taksande Aman B. Upaganlawar Milind J. Umekar Mayur B. Kale Neurodegenerative disorders associated with genes of mitochondria Future Journal of Pharmaceutical Sciences Mitochondrial genes Parkinson’s disease Alzheimer’s disease Huntington’s disease Mutation Friedreich ataxia |
| title | Neurodegenerative disorders associated with genes of mitochondria |
| title_full | Neurodegenerative disorders associated with genes of mitochondria |
| title_fullStr | Neurodegenerative disorders associated with genes of mitochondria |
| title_full_unstemmed | Neurodegenerative disorders associated with genes of mitochondria |
| title_short | Neurodegenerative disorders associated with genes of mitochondria |
| title_sort | neurodegenerative disorders associated with genes of mitochondria |
| topic | Mitochondrial genes Parkinson’s disease Alzheimer’s disease Huntington’s disease Mutation Friedreich ataxia |
| url | https://doi.org/10.1186/s43094-021-00215-5 |
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