Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.

Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.

Optimal norepinephrine levels in the prefrontal cortex (PFC) increase delay-related firing and enhance working memory, whereas stress-related or pathologically high levels of norepinephrine are believed to inhibit working memory via α1 adrenoceptors. However, it has been shown that activation of Gq-...

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Bibliographic Details
Main Authors: Zizhen Zhang, Steven Cordeiro Matos, Sonia Jego, Antoine Adamantidis, Philippe Séguéla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3681776?pdf=render

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