From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit
Introduction: This study aims to evaluate presenting symptoms, clinical and laboratory findings, and treatment modalities of adult patients presenting with mushroom poisoning treated in the intensive care unit (ICU) with special consideration of extracorporeal liver support systems. Materials and me...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nizameddin KOCA
2021-01-01
|
| Series: | Turkish Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1420469 |
| _version_ | 1828028224791117824 |
|---|---|
| author | Remzi Iscimen Nermin Kelebek Girgin Ferda Şöhret Kahveci Gülbahar Çalışkan Elif Ayşe Çizmeci Nurdan Ünlü |
| author_facet | Remzi Iscimen Nermin Kelebek Girgin Ferda Şöhret Kahveci Gülbahar Çalışkan Elif Ayşe Çizmeci Nurdan Ünlü |
| author_sort | Remzi Iscimen |
| collection | DOAJ |
| description | Introduction: This study aims to evaluate presenting symptoms, clinical and laboratory findings, and treatment modalities of adult patients presenting with mushroom poisoning treated in the intensive care unit (ICU) with special consideration of extracorporeal liver support systems.
Materials and methods: Records of patients with mushroom poisoning treated in the ICU between January 2007 and December 2014 were analyzed retrospectively.
Results: Sixteen adult patients were treated in the ICU for mushroom poisoning during the designated study period. Presentation to the hospital was most common during October of each year. Average time from ingestion of mushrooms to first symptoms was 17.81 hours, and to ICU admission was 2.38 days. The most common symptoms were nausea, vomiting and diarrhea. The most common laboratory finding was elevation of liver transaminases. In cases with elevated liver transaminases, penicillin G, silibinin and N-acetyl cysteine were used. Extracorporeal support systems were used in 9 cases. Two cases underwent emergency liver transplantation.
Conclusion: Liver transplantation is the most definitive and effective treatment in indicated cases of mushroom poisoning. Extracorporeal support systems should be considered in the early period both as a treatmet modality on their own or to save time until the definitive treatment is possible. The question of which extracorporeal detoxification technique to use is difficult to answer and controlled clinical trials which compare their efficacy are needed. |
| first_indexed | 2024-04-10T13:48:46Z |
| format | Article |
| id | doaj.art-4e93ba3f876e4057aed93f842c9db76a |
| institution | Directory Open Access Journal |
| issn | 2687-4245 |
| language | English |
| last_indexed | 2024-04-10T13:48:46Z |
| publishDate | 2021-01-01 |
| publisher | Nizameddin KOCA |
| record_format | Article |
| series | Turkish Journal of Internal Medicine |
| spelling | doaj.art-4e93ba3f876e4057aed93f842c9db76a2023-02-15T16:10:49ZengNizameddin KOCATurkish Journal of Internal Medicine2687-42452021-01-0131192510.46310/tjim.8328641881From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unitRemzi Iscimen0Nermin Kelebek Girgin1Ferda Şöhret Kahveci2Gülbahar Çalışkan3Elif Ayşe Çizmeci4Nurdan Ünlü5Uludağ Üniversitesi Tıp FakültesiUludağ Üniversitesi Tıp FakültesiUludağ Üniversitesi Tıp FakültesiT.C. Sağlık Bakanlığı Bursa Şehir HastanesiSunnybrook Health Sciencea Centre, Interdepartmental Division of Critical CareT.C. Sağlık Bakanlığı Adana Şehir HastanesiIntroduction: This study aims to evaluate presenting symptoms, clinical and laboratory findings, and treatment modalities of adult patients presenting with mushroom poisoning treated in the intensive care unit (ICU) with special consideration of extracorporeal liver support systems. Materials and methods: Records of patients with mushroom poisoning treated in the ICU between January 2007 and December 2014 were analyzed retrospectively. Results: Sixteen adult patients were treated in the ICU for mushroom poisoning during the designated study period. Presentation to the hospital was most common during October of each year. Average time from ingestion of mushrooms to first symptoms was 17.81 hours, and to ICU admission was 2.38 days. The most common symptoms were nausea, vomiting and diarrhea. The most common laboratory finding was elevation of liver transaminases. In cases with elevated liver transaminases, penicillin G, silibinin and N-acetyl cysteine were used. Extracorporeal support systems were used in 9 cases. Two cases underwent emergency liver transplantation. Conclusion: Liver transplantation is the most definitive and effective treatment in indicated cases of mushroom poisoning. Extracorporeal support systems should be considered in the early period both as a treatmet modality on their own or to save time until the definitive treatment is possible. The question of which extracorporeal detoxification technique to use is difficult to answer and controlled clinical trials which compare their efficacy are needed.https://dergipark.org.tr/tr/download/article-file/1420469mushroom poisoningselective plasma exchangeactivated charcoalintensive care unit |
| spellingShingle | Remzi Iscimen Nermin Kelebek Girgin Ferda Şöhret Kahveci Gülbahar Çalışkan Elif Ayşe Çizmeci Nurdan Ünlü From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit Turkish Journal of Internal Medicine mushroom poisoning selective plasma exchange activated charcoal intensive care unit |
| title | From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| title_full | From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| title_fullStr | From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| title_full_unstemmed | From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| title_short | From activated charcoal to selective plasma exchange: A retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| title_sort | from activated charcoal to selective plasma exchange a retrospective analysis of mushroom poisoning cases treated in the intensive care unit |
| topic | mushroom poisoning selective plasma exchange activated charcoal intensive care unit |
| url | https://dergipark.org.tr/tr/download/article-file/1420469 |
| work_keys_str_mv | AT remziiscimen fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit AT nerminkelebekgirgin fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit AT ferdasohretkahveci fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit AT gulbaharcalıskan fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit AT elifaysecizmeci fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit AT nurdanunlu fromactivatedcharcoaltoselectiveplasmaexchangearetrospectiveanalysisofmushroompoisoningcasestreatedintheintensivecareunit |