Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers
Lipoic acid synthetase (LIAS) has been demonstrated to play a crucial role in the progression of cancer. Exploring the underlying mechanisms and biological functions of LIAS could have potential therapeutic guidance for cancer treatment. Our study has explored the expression levels and prognostic va...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.952129/full |
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| author | Yuan Cai Yuan Cai Qingchun He Qingchun He Wei Liu Qiuju Liang Bi Peng Jianbo Li Wenqin Zhang Fanhua Kang Qianhui Hong Yuanliang Yan Jinwu Peng Jinwu Peng Jinwu Peng Zhijie Xu Zhijie Xu Zhijie Xu Ning Bai |
| author_facet | Yuan Cai Yuan Cai Qingchun He Qingchun He Wei Liu Qiuju Liang Bi Peng Jianbo Li Wenqin Zhang Fanhua Kang Qianhui Hong Yuanliang Yan Jinwu Peng Jinwu Peng Jinwu Peng Zhijie Xu Zhijie Xu Zhijie Xu Ning Bai |
| author_sort | Yuan Cai |
| collection | DOAJ |
| description | Lipoic acid synthetase (LIAS) has been demonstrated to play a crucial role in the progression of cancer. Exploring the underlying mechanisms and biological functions of LIAS could have potential therapeutic guidance for cancer treatment. Our study has explored the expression levels and prognostic values of LIAS in pan-cancer through several bioinformatics platforms, including TIMER2.0, Gene Expression Profiling Interactive Analysis, version 2 (GEPIA2.0), and Human Protein Atlas (HPA). We found that a high LIAS expression was related to the good prognosis in patients with kidney renal clear cell carcinoma (KIRC), rectum adenocarcinoma (READ), breast cancer, and ovarian cancer. Inversely, a high LIAS expression showed unfavorable prognosis in lung cancer patients. In addition, the genetic alteration, methylation levels, and immune analysis of LIAS in pan-cancer have been evaluated. To elucidate the underlying molecular mechanism of LIAS, we conduct the single-cell sequencing to implicate that LIAS expression was related to hypoxia, angiogenesis, and DNA repair. Thus, these comprehensive pan-cancer analyses have conveyed that LIAS could be potentially significant in the progression of various cancers. Moreover, the LIAS expression could predict the efficacy of immunotherapy in cancer patients. |
| first_indexed | 2024-12-11T19:02:17Z |
| format | Article |
| id | doaj.art-4e947dde5f17479cb69be33e2de58e6d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T19:02:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4e947dde5f17479cb69be33e2de58e6d2022-12-22T00:53:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.952129952129Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancersYuan Cai0Yuan Cai1Qingchun He2Qingchun He3Wei Liu4Qiuju Liang5Bi Peng6Jianbo Li7Wenqin Zhang8Fanhua Kang9Qianhui Hong10Yuanliang Yan11Jinwu Peng12Jinwu Peng13Jinwu Peng14Zhijie Xu15Zhijie Xu16Zhijie Xu17Ning Bai18Department of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaDepartment of Emergency, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency, Xiangya Changde Hospital, Changde, ChinaDepartment of Orthopedic Surgery, The Second Hospital University of South China, Hengyang, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Changde Hospital, Changde, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, ChinaLipoic acid synthetase (LIAS) has been demonstrated to play a crucial role in the progression of cancer. Exploring the underlying mechanisms and biological functions of LIAS could have potential therapeutic guidance for cancer treatment. Our study has explored the expression levels and prognostic values of LIAS in pan-cancer through several bioinformatics platforms, including TIMER2.0, Gene Expression Profiling Interactive Analysis, version 2 (GEPIA2.0), and Human Protein Atlas (HPA). We found that a high LIAS expression was related to the good prognosis in patients with kidney renal clear cell carcinoma (KIRC), rectum adenocarcinoma (READ), breast cancer, and ovarian cancer. Inversely, a high LIAS expression showed unfavorable prognosis in lung cancer patients. In addition, the genetic alteration, methylation levels, and immune analysis of LIAS in pan-cancer have been evaluated. To elucidate the underlying molecular mechanism of LIAS, we conduct the single-cell sequencing to implicate that LIAS expression was related to hypoxia, angiogenesis, and DNA repair. Thus, these comprehensive pan-cancer analyses have conveyed that LIAS could be potentially significant in the progression of various cancers. Moreover, the LIAS expression could predict the efficacy of immunotherapy in cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.952129/fullcuproptosisLIASimmunityprognosispan-cancer |
| spellingShingle | Yuan Cai Yuan Cai Qingchun He Qingchun He Wei Liu Qiuju Liang Bi Peng Jianbo Li Wenqin Zhang Fanhua Kang Qianhui Hong Yuanliang Yan Jinwu Peng Jinwu Peng Jinwu Peng Zhijie Xu Zhijie Xu Zhijie Xu Ning Bai Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers Frontiers in Oncology cuproptosis LIAS immunity prognosis pan-cancer |
| title | Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers |
| title_full | Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers |
| title_fullStr | Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers |
| title_full_unstemmed | Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers |
| title_short | Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers |
| title_sort | comprehensive analysis of the potential cuproptosis related biomarker lias that regulates prognosis and immunotherapy of pan cancers |
| topic | cuproptosis LIAS immunity prognosis pan-cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.952129/full |
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