The microbiome and mosquito vectorial capacity: rich potential for discovery and translation
Abstract Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Microbiome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40168-021-01073-2 |
| _version_ | 1818455098492190720 |
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| author | Cintia Cansado-Utrilla Serena Y. Zhao Philip J. McCall Kerri L. Coon Grant L. Hughes |
| author_facet | Cintia Cansado-Utrilla Serena Y. Zhao Philip J. McCall Kerri L. Coon Grant L. Hughes |
| author_sort | Cintia Cansado-Utrilla |
| collection | DOAJ |
| description | Abstract Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding mosquito–microbe interactions that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required. Video abstract |
| first_indexed | 2024-12-14T22:05:22Z |
| format | Article |
| id | doaj.art-4e952c65b4fd4295acba873be6d33afe |
| institution | Directory Open Access Journal |
| issn | 2049-2618 |
| language | English |
| last_indexed | 2024-12-14T22:05:22Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj.art-4e952c65b4fd4295acba873be6d33afe2022-12-21T22:45:53ZengBMCMicrobiome2049-26182021-05-019111110.1186/s40168-021-01073-2The microbiome and mosquito vectorial capacity: rich potential for discovery and translationCintia Cansado-Utrilla0Serena Y. Zhao1Philip J. McCall2Kerri L. Coon3Grant L. Hughes4Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical MedicineDepartment of Bacteriology, University of Wisconsin-MadisonDepartment of Vector Biology, Liverpool School of Tropical MedicineDepartment of Bacteriology, University of Wisconsin-MadisonDepartments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical MedicineAbstract Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding mosquito–microbe interactions that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required. Video abstracthttps://doi.org/10.1186/s40168-021-01073-2MicrobiomeVectorial capacityDensityCompetenceBitingExtrinsic incubation period |
| spellingShingle | Cintia Cansado-Utrilla Serena Y. Zhao Philip J. McCall Kerri L. Coon Grant L. Hughes The microbiome and mosquito vectorial capacity: rich potential for discovery and translation Microbiome Microbiome Vectorial capacity Density Competence Biting Extrinsic incubation period |
| title | The microbiome and mosquito vectorial capacity: rich potential for discovery and translation |
| title_full | The microbiome and mosquito vectorial capacity: rich potential for discovery and translation |
| title_fullStr | The microbiome and mosquito vectorial capacity: rich potential for discovery and translation |
| title_full_unstemmed | The microbiome and mosquito vectorial capacity: rich potential for discovery and translation |
| title_short | The microbiome and mosquito vectorial capacity: rich potential for discovery and translation |
| title_sort | microbiome and mosquito vectorial capacity rich potential for discovery and translation |
| topic | Microbiome Vectorial capacity Density Competence Biting Extrinsic incubation period |
| url | https://doi.org/10.1186/s40168-021-01073-2 |
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