Targeting NMDA Receptor Complex in Management of Epilepsy
<i>N</i>-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function of these receptors can under...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1297 |
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| author | Shravan Sivakumar Mehdi Ghasemi Steven C. Schachter |
| author_facet | Shravan Sivakumar Mehdi Ghasemi Steven C. Schachter |
| author_sort | Shravan Sivakumar |
| collection | DOAJ |
| description | <i>N</i>-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function of these receptors can underlie the pathophysiology of seizure disorders and epilepsy. Accordingly, NMDAR modulators have been shown to exert anticonvulsive effects in various preclinical models of seizures, as well as in patients with epilepsy. In this review, we provide an update on the pathologic role of NMDARs in epilepsy and an overview of the NMDAR antagonists that have been evaluated as anticonvulsive agents in clinical studies, as well as in preclinical seizure models. |
| first_indexed | 2024-03-09T19:36:30Z |
| format | Article |
| id | doaj.art-4e956cdbc97844a587c3252405e57bf7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:30Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-4e956cdbc97844a587c3252405e57bf72023-11-24T01:52:52ZengMDPI AGPharmaceuticals1424-82472022-10-011510129710.3390/ph15101297Targeting NMDA Receptor Complex in Management of EpilepsyShravan Sivakumar0Mehdi Ghasemi1Steven C. Schachter2Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USADepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USADepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA<i>N</i>-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function of these receptors can underlie the pathophysiology of seizure disorders and epilepsy. Accordingly, NMDAR modulators have been shown to exert anticonvulsive effects in various preclinical models of seizures, as well as in patients with epilepsy. In this review, we provide an update on the pathologic role of NMDARs in epilepsy and an overview of the NMDAR antagonists that have been evaluated as anticonvulsive agents in clinical studies, as well as in preclinical seizure models.https://www.mdpi.com/1424-8247/15/10/1297<i>N</i>-methyl-D-aspartate (NMDA) receptorseizureepilepsyNMDA receptor antagonistclinical trial |
| spellingShingle | Shravan Sivakumar Mehdi Ghasemi Steven C. Schachter Targeting NMDA Receptor Complex in Management of Epilepsy Pharmaceuticals <i>N</i>-methyl-D-aspartate (NMDA) receptor seizure epilepsy NMDA receptor antagonist clinical trial |
| title | Targeting NMDA Receptor Complex in Management of Epilepsy |
| title_full | Targeting NMDA Receptor Complex in Management of Epilepsy |
| title_fullStr | Targeting NMDA Receptor Complex in Management of Epilepsy |
| title_full_unstemmed | Targeting NMDA Receptor Complex in Management of Epilepsy |
| title_short | Targeting NMDA Receptor Complex in Management of Epilepsy |
| title_sort | targeting nmda receptor complex in management of epilepsy |
| topic | <i>N</i>-methyl-D-aspartate (NMDA) receptor seizure epilepsy NMDA receptor antagonist clinical trial |
| url | https://www.mdpi.com/1424-8247/15/10/1297 |
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