Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos.
Predominant fat distribution in the upper body segment evaluated by waist to hip circunference ratio (WHR) has been associated with diabetes mellitus and cardiovascular morbidity excess. To investigate metabolic alterations underlying this risk excess, we selected 2 groups of 10 obese women without...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
1990-12-01
|
| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4597 |
| _version_ | 1828106310276612096 |
|---|---|
| author | J Anselmo F Vaz L G Correia E Pereira F Lima e Silva M T Pires J C Nunes-Corrêa |
| author_facet | J Anselmo F Vaz L G Correia E Pereira F Lima e Silva M T Pires J C Nunes-Corrêa |
| author_sort | J Anselmo |
| collection | DOAJ |
| description | Predominant fat distribution in the upper body segment evaluated by waist to hip circunference ratio (WHR) has been associated with diabetes mellitus and cardiovascular morbidity excess. To investigate metabolic alterations underlying this risk excess, we selected 2 groups of 10 obese women without history of hypertension, menstrual irregularities or oral contraceptives, matched according to age (mean +/- SD): 30.5 +/- 5.3 vs 30.6 +/- 5.8 years and BMI 35.5 +/- 6.5 vs 35.7 +/- 6.7 Kg/m2. Each matched pair had a difference in WHR superior to 0.15 (0.83 +/- 0.04 vs 1.02 +/- 0.05). Insulin and C peptide were determined during an oral glucose tolerance test (75 g). At 30, 60, 90 and 120 minutes differences were significant for glycaemia, insulinaemia and C peptide. Fasting triglycerides were 103 +/- 48 in the lower WHR group vs 164 +/- 84 mg/dl (p less than 0.05); total cholesterol 186.5 +/- 31 vs 215.2 +/- 29.4 mg/dl (p less than 0.05); LDL cholesterol/HDL cholesterol 2.46 +/- 0.89 vs 3.18 +/- 0.96 (p less than 0.05). No significant differences were found in androgenic activity. We conclude that preferential fat distribution in the upper segment is, by itself, an aggravating factor of metabolic alterations associated with obesity, particularly dyslipidaemia and hyperinsulinaemia. |
| first_indexed | 2024-04-11T10:14:59Z |
| format | Article |
| id | doaj.art-4e963ff0045c411095b675609dbd8991 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T10:14:59Z |
| publishDate | 1990-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-4e963ff0045c411095b675609dbd89912022-12-22T04:29:59ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581990-12-013610.20344/amp.4597Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos.J Anselmo0F VazL G CorreiaE PereiraF Lima e SilvaM T PiresJ C Nunes-CorrêaUnidade de Endocrinologia, Hospital Curry Cabral, Lisboa.Predominant fat distribution in the upper body segment evaluated by waist to hip circunference ratio (WHR) has been associated with diabetes mellitus and cardiovascular morbidity excess. To investigate metabolic alterations underlying this risk excess, we selected 2 groups of 10 obese women without history of hypertension, menstrual irregularities or oral contraceptives, matched according to age (mean +/- SD): 30.5 +/- 5.3 vs 30.6 +/- 5.8 years and BMI 35.5 +/- 6.5 vs 35.7 +/- 6.7 Kg/m2. Each matched pair had a difference in WHR superior to 0.15 (0.83 +/- 0.04 vs 1.02 +/- 0.05). Insulin and C peptide were determined during an oral glucose tolerance test (75 g). At 30, 60, 90 and 120 minutes differences were significant for glycaemia, insulinaemia and C peptide. Fasting triglycerides were 103 +/- 48 in the lower WHR group vs 164 +/- 84 mg/dl (p less than 0.05); total cholesterol 186.5 +/- 31 vs 215.2 +/- 29.4 mg/dl (p less than 0.05); LDL cholesterol/HDL cholesterol 2.46 +/- 0.89 vs 3.18 +/- 0.96 (p less than 0.05). No significant differences were found in androgenic activity. We conclude that preferential fat distribution in the upper segment is, by itself, an aggravating factor of metabolic alterations associated with obesity, particularly dyslipidaemia and hyperinsulinaemia.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4597 |
| spellingShingle | J Anselmo F Vaz L G Correia E Pereira F Lima e Silva M T Pires J C Nunes-Corrêa Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. Acta Médica Portuguesa |
| title | Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. |
| title_full | Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. |
| title_fullStr | Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. |
| title_full_unstemmed | Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. |
| title_short | Influência da topografia da gordura corporal na homeostase da glicose e nos lípidos séricos. |
| title_sort | influencia da topografia da gordura corporal na homeostase da glicose e nos lipidos sericos |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4597 |
| work_keys_str_mv | AT janselmo influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT fvaz influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT lgcorreia influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT epereira influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT flimaesilva influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT mtpires influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos AT jcnunescorrea influenciadatopografiadagorduracorporalnahomeostasedaglicoseenoslipidossericos |