Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors

Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors

Human sirtuin 2 (SIRT2), a member of the sirtuin family, has been considered as a promising drug target in cancer, neurodegenerative diseases, type II diabetes, and bacterial infections. Thus, SIRT2 inhibitors have been involved in effective treatment strategies for related diseases. Using previousl...

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Bibliographic Details
Main Authors: Lijiao Wang, Chao Li, Wei Chen, Chen Song, Xing Zhang, Fan Yang, Chen Wang, Yuanyuan Zhang, Shan Qian, Zhouyu Wang, Lingling Yang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
histone deacetylases
sirtuins
SIRT2
SAR studies
molecular docking
Online Access:https://www.mdpi.com/1420-3049/24/15/2724

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