<i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications
Polysaccharide is considered to be the main active ingredient of the genus <i>Lycium</i> L., which is taken from the dried fruit of the famous Chinese herbal medicine and precious tonic known as wolfberry. Traditional uses include nourishing the liver and kidney and improving eyesight, w...
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MDPI AG
2022-07-01
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| author | Bo Wang Lu Han Jun-Mei Liu Jin Zhang Wen Wang Bing-Ge Li Cai-Xia Dong Chang-Cai Bai |
| author_facet | Bo Wang Lu Han Jun-Mei Liu Jin Zhang Wen Wang Bing-Ge Li Cai-Xia Dong Chang-Cai Bai |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | Polysaccharide is considered to be the main active ingredient of the genus <i>Lycium</i> L., which is taken from the dried fruit of the famous Chinese herbal medicine and precious tonic known as wolfberry. Traditional uses include nourishing the liver and kidney and improving eyesight, with widespread use in the clinical practice of traditional Chinese medicine. Many studies have focused on the isolation and identification of the genus <i>Lycium</i> L. polysaccharide and its biological activities. However, the variety of raw materials and the mechanisms of polysaccharides differ. After extraction, the structure and biological activity of the obtained polysaccharides also differ. To date, approximately 58 kinds of polysaccharides have been isolated and purified from the <i>Lycium</i> genus, including water-soluble polysaccharides; homogeneous polysaccharides; pectin polysaccharides; acidic heteropolysaccharides; and arabinogalactans, which are composed of arabinose, glucosamine, galactose, glucose, xylose, mannose, fructose, ribose, galacturonic acid, and glucuronic acid. Pharmacological studies have shown that LBPs exhibit a variety of important biological activities, such as protection of nerves; promotion of reproduction; and anti-inflammatory, hepatoprotective, hypoglycemic, and eyesight-improving activities. The aim this paper is to summarize previous and current references to the isolation process, structural characteristics, and biological activities of the genus <i>Lycium</i> L. polysaccharide. This review will provide a useful reference for further research and application of the genus <i>Lycium</i> L. polysaccharide in the field of functional food and medicine. |
| first_indexed | 2024-03-09T12:35:48Z |
| format | Article |
| id | doaj.art-4e9878a45a084e25b085cdc319559b2b |
| institution | Directory Open Access Journal |
| issn | 2297-8739 |
| language | English |
| last_indexed | 2024-03-09T12:35:48Z |
| publishDate | 2022-07-01 |
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| spelling | doaj.art-4e9878a45a084e25b085cdc319559b2b2023-11-30T22:24:47ZengMDPI AGSeparations2297-87392022-07-019819710.3390/separations9080197<i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological ApplicationsBo Wang0Lu Han1Jun-Mei Liu2Jin Zhang3Wen Wang4Bing-Ge Li5Cai-Xia Dong6Chang-Cai Bai7Department of Pharmacy, Ningxia Hui Autonomous Region People’s Hospital, Yinchuan 750000, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ningxia Medical University Pharmacy College, Ministry of Education, No.692 Sheng-Li Street, Xing-Qing District, Yinchuan 750004, ChinaDepartment of Pharmacy, General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ningxia Medical University Pharmacy College, Ministry of Education, No.692 Sheng-Li Street, Xing-Qing District, Yinchuan 750004, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ningxia Medical University Pharmacy College, Ministry of Education, No.692 Sheng-Li Street, Xing-Qing District, Yinchuan 750004, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ningxia Medical University Pharmacy College, Ministry of Education, No.692 Sheng-Li Street, Xing-Qing District, Yinchuan 750004, ChinaDepartment of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, No. 22, Meteorological Station Road, He-ping District, Tianjin 300070, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ningxia Medical University Pharmacy College, Ministry of Education, No.692 Sheng-Li Street, Xing-Qing District, Yinchuan 750004, ChinaPolysaccharide is considered to be the main active ingredient of the genus <i>Lycium</i> L., which is taken from the dried fruit of the famous Chinese herbal medicine and precious tonic known as wolfberry. Traditional uses include nourishing the liver and kidney and improving eyesight, with widespread use in the clinical practice of traditional Chinese medicine. Many studies have focused on the isolation and identification of the genus <i>Lycium</i> L. polysaccharide and its biological activities. However, the variety of raw materials and the mechanisms of polysaccharides differ. After extraction, the structure and biological activity of the obtained polysaccharides also differ. To date, approximately 58 kinds of polysaccharides have been isolated and purified from the <i>Lycium</i> genus, including water-soluble polysaccharides; homogeneous polysaccharides; pectin polysaccharides; acidic heteropolysaccharides; and arabinogalactans, which are composed of arabinose, glucosamine, galactose, glucose, xylose, mannose, fructose, ribose, galacturonic acid, and glucuronic acid. Pharmacological studies have shown that LBPs exhibit a variety of important biological activities, such as protection of nerves; promotion of reproduction; and anti-inflammatory, hepatoprotective, hypoglycemic, and eyesight-improving activities. The aim this paper is to summarize previous and current references to the isolation process, structural characteristics, and biological activities of the genus <i>Lycium</i> L. polysaccharide. This review will provide a useful reference for further research and application of the genus <i>Lycium</i> L. polysaccharide in the field of functional food and medicine.https://www.mdpi.com/2297-8739/9/8/197LBP<i>Lycium</i>pharmacological activitybiological applicationspolysaccharides |
| spellingShingle | Bo Wang Lu Han Jun-Mei Liu Jin Zhang Wen Wang Bing-Ge Li Cai-Xia Dong Chang-Cai Bai <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications Separations LBP <i>Lycium</i> pharmacological activity biological applications polysaccharides |
| title | <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications |
| title_full | <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications |
| title_fullStr | <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications |
| title_full_unstemmed | <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications |
| title_short | <i>Lycium</i> Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications |
| title_sort | i lycium i genus polysaccharide an overview of its extraction structures pharmacological activities and biological applications |
| topic | LBP <i>Lycium</i> pharmacological activity biological applications polysaccharides |
| url | https://www.mdpi.com/2297-8739/9/8/197 |
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