Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis
Abstract Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis. Gut bacterial dysbiosis contributes to t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.6865 |
| _version_ | 1827320434078515200 |
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| author | Xinliang Liu Ying Li Meichen Gu Tiankai Xu Chuanlei Wang Pengyu Chang |
| author_facet | Xinliang Liu Ying Li Meichen Gu Tiankai Xu Chuanlei Wang Pengyu Chang |
| author_sort | Xinliang Liu |
| collection | DOAJ |
| description | Abstract Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis. Gut bacterial dysbiosis contributes to the pathogenesis of RE. Mild to moderate depressive symptoms can be observed in patients with RE in clinical settings; however, the rate of these symptoms has not been reported. Studies have demonstrated that gut bacterial dysbiosis induces depression. In the state of comorbidity, RE and depression may be understood as local and abscopal manifestations of gut bacterial disorders. The ability of comorbid depression to worsen inflammatory bowel disease (IBD) has long been demonstrated and is associated with dysfunction of cholinergic neural anti‐inflammatory pathways. There is a lack of direct evidence for RE comorbid with depression. It is widely accepted that RE shares similar pathophysiologic mechanisms with IBD. Therefore, we may be able to draw on the findings of the relationship between IBD and depression. This review will explore the relationship between gut bacteria, RE, and depression in light of the available evidence and indicate a method for investigating the mechanisms of RE combined with depression. We will also describe new developments in the treatment of RE with probiotics, prebiotics, and fecal microbial transplantation. |
| first_indexed | 2024-04-25T00:45:03Z |
| format | Article |
| id | doaj.art-4e99412496f140d8803dde880c861593 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-25T00:45:03Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-4e99412496f140d8803dde880c8615932024-03-12T04:52:34ZengWileyCancer Medicine2045-76342024-02-01134n/an/a10.1002/cam4.6865Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosisXinliang Liu0Ying Li1Meichen Gu2Tiankai Xu3Chuanlei Wang4Pengyu Chang5Department of Radiation Oncology and Therapy The First Hospital of Jilin University Changchun ChinaDepartment of Radiation Oncology and Therapy The First Hospital of Jilin University Changchun ChinaDepartment of Radiation Oncology and Therapy The First Hospital of Jilin University Changchun ChinaDepartment of Radiation Oncology and Therapy The First Hospital of Jilin University Changchun ChinaDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center The First Hospital of Jilin University Changchun ChinaDepartment of Radiation Oncology and Therapy The First Hospital of Jilin University Changchun ChinaAbstract Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis. Gut bacterial dysbiosis contributes to the pathogenesis of RE. Mild to moderate depressive symptoms can be observed in patients with RE in clinical settings; however, the rate of these symptoms has not been reported. Studies have demonstrated that gut bacterial dysbiosis induces depression. In the state of comorbidity, RE and depression may be understood as local and abscopal manifestations of gut bacterial disorders. The ability of comorbid depression to worsen inflammatory bowel disease (IBD) has long been demonstrated and is associated with dysfunction of cholinergic neural anti‐inflammatory pathways. There is a lack of direct evidence for RE comorbid with depression. It is widely accepted that RE shares similar pathophysiologic mechanisms with IBD. Therefore, we may be able to draw on the findings of the relationship between IBD and depression. This review will explore the relationship between gut bacteria, RE, and depression in light of the available evidence and indicate a method for investigating the mechanisms of RE combined with depression. We will also describe new developments in the treatment of RE with probiotics, prebiotics, and fecal microbial transplantation.https://doi.org/10.1002/cam4.6865depressiondysbiosisgut bacteriaHPAradiation enteropathy |
| spellingShingle | Xinliang Liu Ying Li Meichen Gu Tiankai Xu Chuanlei Wang Pengyu Chang Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis Cancer Medicine depression dysbiosis gut bacteria HPA radiation enteropathy |
| title | Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis |
| title_full | Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis |
| title_fullStr | Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis |
| title_full_unstemmed | Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis |
| title_short | Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis |
| title_sort | radiation enteropathy related depression a neglectable course of disease by gut bacterial dysbiosis |
| topic | depression dysbiosis gut bacteria HPA radiation enteropathy |
| url | https://doi.org/10.1002/cam4.6865 |
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