Cerebral Innate Immunity in Drosophila Melanogaster
Modeling innate immunity in <em>Drosophila melanogaster</em> has a rich history that includes ground-breaking discoveries in pathogen detection and signaling. These studies revealed the evolutionary conservation of innate immune pathways and mechanisms of pathogen detection, resulting in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2015-03-01
|
| Series: | AIMS Neuroscience |
| Subjects: | |
| Online Access: | http://www.aimspress.com/neuroscience/article/219/fulltext.html |
| _version_ | 1819077298309038080 |
|---|---|
| author | Brian P. Leung Kevin R. Doty Terrence Town |
| author_facet | Brian P. Leung Kevin R. Doty Terrence Town |
| author_sort | Brian P. Leung |
| collection | DOAJ |
| description | Modeling innate immunity in <em>Drosophila melanogaster</em> has a rich history that includes ground-breaking discoveries in pathogen detection and signaling. These studies revealed the evolutionary conservation of innate immune pathways and mechanisms of pathogen detection, resulting in an explosion of findings in the innate immunity field. In <em>D. melanogaster</em>, studies have focused primarily on responses driven by the larval fat body and hemocytes, analogs to vertebrate liver and macrophages, respectively. Aside from pathogen detection, many recent mammalian studies associate innate immune pathways with development and disease pathogenesis. Importantly, these studies stress that the innate immune response is integral to maintain central nervous system (CNS) health. Microglia, which are the vertebrate CNS mononuclear phagocytes, drive vertebrate cerebral innate immunity. The invertebrate CNS contains microglial-like cells-ensheathing glia and reticular glia-that could be used to answer basic questions regarding the evolutionarily conserved innate immune processes in CNS development and health. A deeper understanding of the relationship between <em>D. melanogaster</em> phagocytic microglial-like cells and vertebrate microglia will be key to answering basic and translational questions related to cerebral innate immunity. |
| first_indexed | 2024-12-21T18:54:58Z |
| format | Article |
| id | doaj.art-4e9b8e8b4508481e95a28d19ac74effa |
| institution | Directory Open Access Journal |
| issn | 2373-7972 |
| language | English |
| last_indexed | 2024-12-21T18:54:58Z |
| publishDate | 2015-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj.art-4e9b8e8b4508481e95a28d19ac74effa2022-12-21T18:53:39ZengAIMS PressAIMS Neuroscience2373-79722015-03-0121355110.3934/Neuroscience.2015.1.3520150105Cerebral Innate Immunity in Drosophila MelanogasterBrian P. Leung0Kevin R. Doty1Terrence Town2Zilkha Neurogenetic Institute, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USAZilkha Neurogenetic Institute, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USAZilkha Neurogenetic Institute, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USAModeling innate immunity in <em>Drosophila melanogaster</em> has a rich history that includes ground-breaking discoveries in pathogen detection and signaling. These studies revealed the evolutionary conservation of innate immune pathways and mechanisms of pathogen detection, resulting in an explosion of findings in the innate immunity field. In <em>D. melanogaster</em>, studies have focused primarily on responses driven by the larval fat body and hemocytes, analogs to vertebrate liver and macrophages, respectively. Aside from pathogen detection, many recent mammalian studies associate innate immune pathways with development and disease pathogenesis. Importantly, these studies stress that the innate immune response is integral to maintain central nervous system (CNS) health. Microglia, which are the vertebrate CNS mononuclear phagocytes, drive vertebrate cerebral innate immunity. The invertebrate CNS contains microglial-like cells-ensheathing glia and reticular glia-that could be used to answer basic questions regarding the evolutionarily conserved innate immune processes in CNS development and health. A deeper understanding of the relationship between <em>D. melanogaster</em> phagocytic microglial-like cells and vertebrate microglia will be key to answering basic and translational questions related to cerebral innate immunity.http://www.aimspress.com/neuroscience/article/219/fulltext.htmlBrain<i>Drosophila melanogaster</i>gliamicroglianeuroimmunologyneuroinflammation |
| spellingShingle | Brian P. Leung Kevin R. Doty Terrence Town Cerebral Innate Immunity in Drosophila Melanogaster AIMS Neuroscience Brain <i>Drosophila melanogaster</i> glia microglia neuroimmunology neuroinflammation |
| title | Cerebral Innate Immunity in Drosophila Melanogaster |
| title_full | Cerebral Innate Immunity in Drosophila Melanogaster |
| title_fullStr | Cerebral Innate Immunity in Drosophila Melanogaster |
| title_full_unstemmed | Cerebral Innate Immunity in Drosophila Melanogaster |
| title_short | Cerebral Innate Immunity in Drosophila Melanogaster |
| title_sort | cerebral innate immunity in drosophila melanogaster |
| topic | Brain <i>Drosophila melanogaster</i> glia microglia neuroimmunology neuroinflammation |
| url | http://www.aimspress.com/neuroscience/article/219/fulltext.html |
| work_keys_str_mv | AT brianpleung cerebralinnateimmunityindrosophilamelanogaster AT kevinrdoty cerebralinnateimmunityindrosophilamelanogaster AT terrencetown cerebralinnateimmunityindrosophilamelanogaster |