One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry
BackgroundCardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167738/full |
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| author | Miloud Cherbi Miloud Cherbi Eric Bonnefoy Nicolas Lamblin Edouard Gerbaud Edouard Gerbaud Laurent Bonello Laurent Bonello Laurent Bonello François Roubille Bruno Levy Sebastien Champion Pascal Lim Pascal Lim Francis Schneider Meyer Elbaz Meyer Elbaz Hadi Khachab Jeremy Bourenne Marie-France Seronde Guillaume Schurtz Brahim Harbaoui Brahim Harbaoui Gerald Vanzetto Nicolas Combaret Vincent Labbe Benjamin Marchandot Benoit Lattuca Caroline Biendel-Picquet Caroline Biendel-Picquet Guillaume Leurent Etienne Puymirat Etienne Puymirat Philippe Maury Philippe Maury Clément Delmas Clément Delmas Clément Delmas |
| author_facet | Miloud Cherbi Miloud Cherbi Eric Bonnefoy Nicolas Lamblin Edouard Gerbaud Edouard Gerbaud Laurent Bonello Laurent Bonello Laurent Bonello François Roubille Bruno Levy Sebastien Champion Pascal Lim Pascal Lim Francis Schneider Meyer Elbaz Meyer Elbaz Hadi Khachab Jeremy Bourenne Marie-France Seronde Guillaume Schurtz Brahim Harbaoui Brahim Harbaoui Gerald Vanzetto Nicolas Combaret Vincent Labbe Benjamin Marchandot Benoit Lattuca Caroline Biendel-Picquet Caroline Biendel-Picquet Guillaume Leurent Etienne Puymirat Etienne Puymirat Philippe Maury Philippe Maury Clément Delmas Clément Delmas Clément Delmas |
| author_sort | Miloud Cherbi |
| collection | DOAJ |
| description | BackgroundCardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes between SVT-triggered and non-SVT-triggered CS.MethodsFRENSHOCK is a French prospective registry including 772 CS patients from 49 centers. For each patient, the investigator could report 1–3 CS triggers from a pre-established list (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance, and others). In this study, 1-year outcomes [rehospitalizations, mortality, heart transplantation (HTx), ventricular assist devices (VAD)] were analyzed and adjusted for independent predictive factors.ResultsAmong 769 CS patients included, 100 were SVT-triggered (13%), of which 65 had SVT as an exclusive trigger (8.5%). SVT-triggered CS patients exhibited a higher proportion of male individuals with a more frequent history of cardiomyopathy or chronic kidney disease and more profound CS (biventricular failure and multiorgan failure). At 1 year, there was no difference in all-cause mortality (43% vs. 45.3%, adjusted HR 0.9 (95% CI 0.59–1.39), p = 0.64), need for HTx or VAD [10% vs. 10%, aOR 0.88 (0.41–1.88), p = 0.74], or rehospitalizations [49.4% vs. 44.4%, aOR 1.24 (0.78–1.98), p = 0.36]. Patients with SVT as an exclusive trigger presented more 1-year rehospitalizations [52.8% vs. 43.3%, aOR 3.74 (1.05–10.5), p = 0.01].ConclusionSVT is a frequent trigger of CS alone or in association in more than 10% of miscellaneous CS cases. Although SVT-triggered CS patients were more comorbid with more pre-existing cardiomyopathies and HF incidences, they presented similar rates of mortality, HTx, and VAD at 1 year, arguing for a better overall prognosis.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier: NCT02703038. |
| first_indexed | 2024-03-12T02:32:44Z |
| format | Article |
| id | doaj.art-4e9cab32223c4b198c22e913199a91a7 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T02:32:44Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-4e9cab32223c4b198c22e913199a91a72023-09-05T06:53:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.11677381167738One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registryMiloud Cherbi0Miloud Cherbi1Eric Bonnefoy2Nicolas Lamblin3Edouard Gerbaud4Edouard Gerbaud5Laurent Bonello6Laurent Bonello7Laurent Bonello8François Roubille9Bruno Levy10Sebastien Champion11Pascal Lim12Pascal Lim13Francis Schneider14Meyer Elbaz15Meyer Elbaz16Hadi Khachab17Jeremy Bourenne18Marie-France Seronde19Guillaume Schurtz20Brahim Harbaoui21Brahim Harbaoui22Gerald Vanzetto23Nicolas Combaret24Vincent Labbe25Benjamin Marchandot26Benoit Lattuca27Caroline Biendel-Picquet28Caroline Biendel-Picquet29Guillaume Leurent30Etienne Puymirat31Etienne Puymirat32Philippe Maury33Philippe Maury34Clément Delmas35Clément Delmas36Clément Delmas37Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, FranceIntensive Cardiac Care Unit, Lyon Brom University Hospital, Lyon, FranceUrgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, FranceIntensive Cardiac Care Unit and Interventional Cardiology, Hôpital Cardiologique du Haut Lévêque, Pessac, FranceBordeaux Cardio-Thoracic Research Centre, U1045, Bordeaux University, Hôpital Xavier Arnozan, Pessac, FranceCardiology Department, Hopital Nord, AP-HM, Aix-Marseille Université, Marseille, FranceIntensive Care Unit, Department of Cardiology, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille, FranceMediterranean Association for Research and Studies in Cardiology (MARS Cardio), Marseille, France0Cardiology Department, PhyMedExp, Université de Montpellier, INSERM, CNRS, INI-CRT, CHU de Montpellier, Montpellier, France1Réanimation Médicale Brabois, CHRU Nancy, Vandoeuvre-les Nancy, France2Anesthesiology and Intensive Care Department, Clinique de Parly 2, Ramsay Générale de Santé, Le Chesnay, France3Univ Paris Est Créteil, INSERM, IMRB, Créteil, France4Cardiology Department, AP-HP, Hôpital Universitaire Henri-Mondor, Service de Cardiologie, Créteil, France5Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, FranceIntensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France6Intensive Cardiac Care Unit, Cardiology Department, CH d'Aix-en-Provence, Aix-en-Provence, France7Service de Réanimation des Urgences, AP-HM, Hôpital de La Timone, Marseille, France8Service de Cardiologie CHU, Besançon, FranceUrgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, France9Cardiology Department, Hôpital Croix-Rousse and Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France0University of Lyon, CREATIS, UMR5220, INSERM U1044, INSA-15, Lyon, France1Department of Cardiology, Hôpital de Grenoble, La Tronche, France2Department of Cardiology, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France3Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Tenon,Paris, France4Université de Strasbourg, Pôle D'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France5Department of Cardiology, Nîmes University Hospital, Montpellier University, Nîmes, FranceIntensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France6Department of Cardiology, CHU Rennes, Inserm, LTSI—UMR 1099, Univ Rennes 1, Rennes, France7Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Paris, France8Université de Paris, Paris, FranceIntensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, FranceIntensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, FranceInstitute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France9REICATRA, Institut Saint Jacques, CHU de Toulouse, ToulouseFranceBackgroundCardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes between SVT-triggered and non-SVT-triggered CS.MethodsFRENSHOCK is a French prospective registry including 772 CS patients from 49 centers. For each patient, the investigator could report 1–3 CS triggers from a pre-established list (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance, and others). In this study, 1-year outcomes [rehospitalizations, mortality, heart transplantation (HTx), ventricular assist devices (VAD)] were analyzed and adjusted for independent predictive factors.ResultsAmong 769 CS patients included, 100 were SVT-triggered (13%), of which 65 had SVT as an exclusive trigger (8.5%). SVT-triggered CS patients exhibited a higher proportion of male individuals with a more frequent history of cardiomyopathy or chronic kidney disease and more profound CS (biventricular failure and multiorgan failure). At 1 year, there was no difference in all-cause mortality (43% vs. 45.3%, adjusted HR 0.9 (95% CI 0.59–1.39), p = 0.64), need for HTx or VAD [10% vs. 10%, aOR 0.88 (0.41–1.88), p = 0.74], or rehospitalizations [49.4% vs. 44.4%, aOR 1.24 (0.78–1.98), p = 0.36]. Patients with SVT as an exclusive trigger presented more 1-year rehospitalizations [52.8% vs. 43.3%, aOR 3.74 (1.05–10.5), p = 0.01].ConclusionSVT is a frequent trigger of CS alone or in association in more than 10% of miscellaneous CS cases. Although SVT-triggered CS patients were more comorbid with more pre-existing cardiomyopathies and HF incidences, they presented similar rates of mortality, HTx, and VAD at 1 year, arguing for a better overall prognosis.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier: NCT02703038.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167738/fullcardiogenic shocksupraventricular tachycardiaepidemiologyprognosismortality |
| spellingShingle | Miloud Cherbi Miloud Cherbi Eric Bonnefoy Nicolas Lamblin Edouard Gerbaud Edouard Gerbaud Laurent Bonello Laurent Bonello Laurent Bonello François Roubille Bruno Levy Sebastien Champion Pascal Lim Pascal Lim Francis Schneider Meyer Elbaz Meyer Elbaz Hadi Khachab Jeremy Bourenne Marie-France Seronde Guillaume Schurtz Brahim Harbaoui Brahim Harbaoui Gerald Vanzetto Nicolas Combaret Vincent Labbe Benjamin Marchandot Benoit Lattuca Caroline Biendel-Picquet Caroline Biendel-Picquet Guillaume Leurent Etienne Puymirat Etienne Puymirat Philippe Maury Philippe Maury Clément Delmas Clément Delmas Clément Delmas One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry Frontiers in Cardiovascular Medicine cardiogenic shock supraventricular tachycardia epidemiology prognosis mortality |
| title | One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry |
| title_full | One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry |
| title_fullStr | One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry |
| title_full_unstemmed | One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry |
| title_short | One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry |
| title_sort | one year outcomes in cardiogenic shock triggered by supraventricular tachycardia an analysis of the frenshock multicenter prospective registry |
| topic | cardiogenic shock supraventricular tachycardia epidemiology prognosis mortality |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1167738/full |
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