Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study
Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral cortex, stimulates the mitochondrial respiratory chain...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/14/2017 |
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| author | Dan V. Iosifescu Xiaotong Song Maia B. Gersten Arwa Adib Yoonju Cho Katherine M. Collins Kathy F. Yates Aura M. Hurtado-Puerto Kayla M. McEachern Ricardo S. Osorio Paolo Cassano |
| author_facet | Dan V. Iosifescu Xiaotong Song Maia B. Gersten Arwa Adib Yoonju Cho Katherine M. Collins Kathy F. Yates Aura M. Hurtado-Puerto Kayla M. McEachern Ricardo S. Osorio Paolo Cassano |
| author_sort | Dan V. Iosifescu |
| collection | DOAJ |
| description | Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral cortex, stimulates the mitochondrial respiratory chain, and increases cerebral blood flow. Preliminary data suggests t-PBM may be efficacious in improving cognition in people with early AD and amnestic mild cognitive impairment (aMCI). Methods: In this randomized, double-blind, placebo-controlled study with aMCI and early AD participants, we will test the efficacy, safety, and impact on cognition of 24 sessions of t-PBM delivered over 8 weeks. Brain mechanisms of t-PBM in this population will be explored by testing whether the baseline tau burden (measured with <sup>18</sup>F-MK6240), or changes in mitochondrial function over 8 weeks (assessed with <sup>31</sup>P-MRSI), moderates the changes observed in cognitive functions after t-PBM therapy. We will also use changes in the fMRI Blood-Oxygenation-Level-Dependent (BOLD) signal after a single treatment to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow. Conclusion: This study will test whether t-PBM, a low-cost, accessible, and user-friendly intervention, has the potential to improve cognition and function in an aMCI and early AD population. |
| first_indexed | 2024-03-11T01:01:32Z |
| format | Article |
| id | doaj.art-4e9d65be0a2545faac12e9752648bbd7 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T01:01:32Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-4e9d65be0a2545faac12e9752648bbd72023-11-18T19:32:45ZengMDPI AGHealthcare2227-90322023-07-011114201710.3390/healthcare11142017Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) StudyDan V. Iosifescu0Xiaotong Song1Maia B. Gersten2Arwa Adib3Yoonju Cho4Katherine M. Collins5Kathy F. Yates6Aura M. Hurtado-Puerto7Kayla M. McEachern8Ricardo S. Osorio9Paolo Cassano10Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USADepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USADepartment of Psychiatry, Division of Neuropsychiatry, Massachusetts General Hospital, Boston, MA 02129, USADepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USADepartment of Psychiatry, Division of Neuropsychiatry, Massachusetts General Hospital, Boston, MA 02129, USANathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USANathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USADepartment of Psychiatry, Division of Neuropsychiatry, Massachusetts General Hospital, Boston, MA 02129, USADepartment of Psychiatry, Division of Neuropsychiatry, Massachusetts General Hospital, Boston, MA 02129, USANathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USADepartment of Psychiatry, Division of Neuropsychiatry, Massachusetts General Hospital, Boston, MA 02129, USABackground: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral cortex, stimulates the mitochondrial respiratory chain, and increases cerebral blood flow. Preliminary data suggests t-PBM may be efficacious in improving cognition in people with early AD and amnestic mild cognitive impairment (aMCI). Methods: In this randomized, double-blind, placebo-controlled study with aMCI and early AD participants, we will test the efficacy, safety, and impact on cognition of 24 sessions of t-PBM delivered over 8 weeks. Brain mechanisms of t-PBM in this population will be explored by testing whether the baseline tau burden (measured with <sup>18</sup>F-MK6240), or changes in mitochondrial function over 8 weeks (assessed with <sup>31</sup>P-MRSI), moderates the changes observed in cognitive functions after t-PBM therapy. We will also use changes in the fMRI Blood-Oxygenation-Level-Dependent (BOLD) signal after a single treatment to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow. Conclusion: This study will test whether t-PBM, a low-cost, accessible, and user-friendly intervention, has the potential to improve cognition and function in an aMCI and early AD population.https://www.mdpi.com/2227-9032/11/14/2017Alzheimer’s disease (AD)transcranial photobiomodulation (t-PBM)neuromodulationcognitionfunctional MRI (fMRI)Phosphorus magnetic resonance spectroscopic imaging (31P-MRSI) |
| spellingShingle | Dan V. Iosifescu Xiaotong Song Maia B. Gersten Arwa Adib Yoonju Cho Katherine M. Collins Kathy F. Yates Aura M. Hurtado-Puerto Kayla M. McEachern Ricardo S. Osorio Paolo Cassano Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study Healthcare Alzheimer’s disease (AD) transcranial photobiomodulation (t-PBM) neuromodulation cognition functional MRI (fMRI) Phosphorus magnetic resonance spectroscopic imaging (31P-MRSI) |
| title | Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study |
| title_full | Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study |
| title_fullStr | Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study |
| title_full_unstemmed | Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study |
| title_short | Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study |
| title_sort | protocol report on the transcranial photobiomodulation for alzheimer s disease trap ad study |
| topic | Alzheimer’s disease (AD) transcranial photobiomodulation (t-PBM) neuromodulation cognition functional MRI (fMRI) Phosphorus magnetic resonance spectroscopic imaging (31P-MRSI) |
| url | https://www.mdpi.com/2227-9032/11/14/2017 |
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