Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury

Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury

The recovery of spinal cord injury (SCI) is closely associated with the obstruction of oligodendrocyte progenitor cell (OPC) differentiation, which ultimately induces the inability to generate newly formed myelin. To address the concern, drug-based methods may be the most practical and feasible way,...

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Bibliographic Details
Main Authors: Lu-Yao Tong, Yong-Bing Deng, Wei-Hong Du, Wen-Zhu Zhou, Xin-Yu Liao, Xue Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
clemastine
oligodendrocyte progenitor cells
ERK1/2
muscarinic receptor
myelin regulatory factor
oligodendrocyte transcription factor 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.914153/full

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