Potential Hepatoprotective Effects of <i>Chamaecyparis lawsoniana</i> against Methotrexate-Induced Liver Injury: Integrated Phytochemical Profiling, Target Network Analysis, and Experimental Validation

Potential Hepatoprotective Effects of <i>Chamaecyparis lawsoniana</i> against Methotrexate-Induced Liver Injury: Integrated Phytochemical Profiling, Target Network Analysis, and Experimental Validation

Methotrexate (MTX) therapy encounters significant limitations due to the significant concern of drug-induced liver injury (DILI), which poses a significant challenge to its usage. To mitigate the deleterious effects of MTX on hepatic function, researchers have explored plant sources to discover pote...

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Bibliographic Details
Main Authors: Eman Fikry, Raha Orfali, Shaimaa S. El-Sayed, Shagufta Perveen, Safina Ghafar, Azza M. El-Shafae, Maher M. El-Domiaty, Nora Tawfeek
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antioxidants
Subjects:
<i>Chamaecyparis lawsoniana</i>
UPLC-ESI-MS/MS
acute liver injury
network pharmacology
docking
Online Access:https://www.mdpi.com/2076-3921/12/12/2118

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