Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease
IntroductionDopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to w...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.949406/full |
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| author | Andrew Dawson Paola Ortelli Paola Ortelli Adrian Carter Davide Ferrazzoli Davide Ferrazzoli Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Andrew Evans Yann Chye Valentina Lorenzetti Giuseppe Frazzitta Murat Yücel |
| author_facet | Andrew Dawson Paola Ortelli Paola Ortelli Adrian Carter Davide Ferrazzoli Davide Ferrazzoli Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Andrew Evans Yann Chye Valentina Lorenzetti Giuseppe Frazzitta Murat Yücel |
| author_sort | Andrew Dawson |
| collection | DOAJ |
| description | IntroductionDopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to work for rewards) and choice impulsivity (preferring smaller, immediate rewards over larger, delayed rewards) in PD patients with ICBs (PD + ICBs).MethodsTo deeply understand this evidence, we studied 24 PD + ICBs and 28 PD patients without ICBs (PD-ICBs). First of all, patients underwent the assessment of impulsivity traits, mood, anxiety, and addiction condition. We further administered robust objective and subjective measures of specific aspects of motivation. Finally, we explored whether these processes might link to any heightened antisocial behavior (aggression and risky driving) in PD + ICBs.ResultsHigh levels of positive urgency trait characterized PD + ICBs. They choose to exert more effort for rewards under the conditions of low and medium reward probability and as reward magnitude increases. Findings on choice impulsivity show a great tendency to delay discounting in PD + ICBs, other than a high correlation between delay and probability discounting. In addition, we found what appears to be the first evidence of heightened reactive aggression in PD patients with ICBs. Exacerbated incentive motivation and delay discounting trended toward positively predicting reactive aggression in PD + ICBs.DiscussionOur promising results suggest that there might be immense value in future large-scale studies adopting a transdiagnostic neurocognitive endophenotype approach to understanding and predicting the addictive and aggressive behaviors that can arise from dopaminergic medication in PD. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-10T22:18:29Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-4ea158f57d154775ae6b099292bd10682023-01-18T05:05:19ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532023-01-011610.3389/fnbeh.2022.949406949406Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's diseaseAndrew Dawson0Paola Ortelli1Paola Ortelli2Adrian Carter3Davide Ferrazzoli4Davide Ferrazzoli5Nadeeka N. Dissanayaka6Nadeeka N. Dissanayaka7Nadeeka N. Dissanayaka8Andrew Evans9Yann Chye10Valentina Lorenzetti11Giuseppe Frazzitta12Murat Yücel13Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, AustraliaDepartment of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Vipiteno-Sterzing, ItalyDepartment of Movement Disorders and Brain Injury Rehabilitation, “Moriggia-Pelascini” Hospital, Como, ItalyMonash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, AustraliaDepartment of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Vipiteno-Sterzing, ItalyDepartment of Movement Disorders and Brain Injury Rehabilitation, “Moriggia-Pelascini” Hospital, Como, ItalyFaculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Herston, QLD, AustraliaDepartment of Neurology, Royal Brisbane and Women's Hospital, Herston, QLD, AustraliaSchool of Psychology, The University of Queensland, St. Lucia, QLD, AustraliaDepartment of Movement Disorders, The Royal Melbourne Hospital, Parkville, VIC, AustraliaMonash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, AustraliaSchool of Psychology, Australian Catholic University, Fitzroy, VIC, AustraliaMIRT ParkProject, Livorno, ItalyMonash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, AustraliaIntroductionDopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to work for rewards) and choice impulsivity (preferring smaller, immediate rewards over larger, delayed rewards) in PD patients with ICBs (PD + ICBs).MethodsTo deeply understand this evidence, we studied 24 PD + ICBs and 28 PD patients without ICBs (PD-ICBs). First of all, patients underwent the assessment of impulsivity traits, mood, anxiety, and addiction condition. We further administered robust objective and subjective measures of specific aspects of motivation. Finally, we explored whether these processes might link to any heightened antisocial behavior (aggression and risky driving) in PD + ICBs.ResultsHigh levels of positive urgency trait characterized PD + ICBs. They choose to exert more effort for rewards under the conditions of low and medium reward probability and as reward magnitude increases. Findings on choice impulsivity show a great tendency to delay discounting in PD + ICBs, other than a high correlation between delay and probability discounting. In addition, we found what appears to be the first evidence of heightened reactive aggression in PD patients with ICBs. Exacerbated incentive motivation and delay discounting trended toward positively predicting reactive aggression in PD + ICBs.DiscussionOur promising results suggest that there might be immense value in future large-scale studies adopting a transdiagnostic neurocognitive endophenotype approach to understanding and predicting the addictive and aggressive behaviors that can arise from dopaminergic medication in PD.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.949406/fullParkinson's diseasedopamine replacement therapyaddictionmotivationimpulsivityaggression |
| spellingShingle | Andrew Dawson Paola Ortelli Paola Ortelli Adrian Carter Davide Ferrazzoli Davide Ferrazzoli Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Nadeeka N. Dissanayaka Andrew Evans Yann Chye Valentina Lorenzetti Giuseppe Frazzitta Murat Yücel Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease Frontiers in Behavioral Neuroscience Parkinson's disease dopamine replacement therapy addiction motivation impulsivity aggression |
| title | Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease |
| title_full | Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease |
| title_fullStr | Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease |
| title_full_unstemmed | Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease |
| title_short | Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease |
| title_sort | motivational and myopic mechanisms underlying dopamine medication induced impulsive compulsive behaviors in parkinson s disease |
| topic | Parkinson's disease dopamine replacement therapy addiction motivation impulsivity aggression |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.949406/full |
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