Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

Abstract Background Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenot...

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Bibliographic Details
Main Authors: Huakang Zhou, Dilaware Khan, Sajid Muhammad Hussain, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Inflammation
Subjects:
Oxidative stress
Endothelial cells
Cellular senescence
Inflammation
Colchicine
NFκ-B
Online Access:https://doi.org/10.1186/s12950-023-00366-7

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