Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test
<i>Background and objective:</i> The health supplement bovine colostrum reportedly improves immunity and regulates intestinal homeostasis. Reliable assessment methods are needed to ensure the satisfactory biological activity of all marketed colostrum products. Of the well-established eff...
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MDPI AG
2020-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/10/495 |
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| author | Maciej Hałasa Dominika Maciejewska-Markiewicz Magdalena Baśkiewicz-Hałasa Krzysztof Safranow Ewa Stachowska |
| author_facet | Maciej Hałasa Dominika Maciejewska-Markiewicz Magdalena Baśkiewicz-Hałasa Krzysztof Safranow Ewa Stachowska |
| author_sort | Maciej Hałasa |
| collection | DOAJ |
| description | <i>Background and objective:</i> The health supplement bovine colostrum reportedly improves immunity and regulates intestinal homeostasis. Reliable assessment methods are needed to ensure the satisfactory biological activity of all marketed colostrum products. Of the well-established effects of colostrum use, the restoration of appropriate intestinal permeability assessed with the lactulose/mannitol (L/M) differential sugar absorption test upon supplementation with colostrum has been consistently observed. Milking time after delivery is one of the factors that influences the composition of bovine colostrum, which causes a rapid decrease in bioactive components. <i>Materials and methods:</i> We use the L/M test to evaluate the intestinal permeability reduction upon supplementation with colostrum (2 × 500 mg) harvested at various times after delivery (2, 24, and 72 h) or a placebo (whey). In our randomized, double-blind placebo-controlled (DBPC) trial, 31 healthy athletes were divided into four groups and assessed at baseline and after the intervention. <i>Results:</i> The trial revealed that only colostrum collected after 2 h and 24 h caused a significant reduction of intestinal permeability. The comparison of post-intervention vs. baseline Δ values produced statistically significant results for 2 h colostrum versus the placebo and 72 h colostrum groups. <i>Conclusions:</i> We conclude that the change of bovine colostrum composition over the first three days of lactation is accompanied by a decrease in its biological activity as measured with the L/M test. This test may offer a biological quality measure for colostrum. |
| first_indexed | 2024-03-12T06:50:04Z |
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| language | English |
| last_indexed | 2024-03-12T06:50:04Z |
| publishDate | 2020-09-01 |
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| series | Medicina |
| spelling | doaj.art-4ea40984b1f8422cbd9a88362467e8ae2023-09-03T00:18:15ZengMDPI AGMedicina1010-660X2020-09-015649549510.3390/medicina56100495Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability TestMaciej Hałasa0Dominika Maciejewska-Markiewicz1Magdalena Baśkiewicz-Hałasa2Krzysztof Safranow3Ewa Stachowska4Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University, 70-204 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University, 70-204 Szczecin, Poland<i>Background and objective:</i> The health supplement bovine colostrum reportedly improves immunity and regulates intestinal homeostasis. Reliable assessment methods are needed to ensure the satisfactory biological activity of all marketed colostrum products. Of the well-established effects of colostrum use, the restoration of appropriate intestinal permeability assessed with the lactulose/mannitol (L/M) differential sugar absorption test upon supplementation with colostrum has been consistently observed. Milking time after delivery is one of the factors that influences the composition of bovine colostrum, which causes a rapid decrease in bioactive components. <i>Materials and methods:</i> We use the L/M test to evaluate the intestinal permeability reduction upon supplementation with colostrum (2 × 500 mg) harvested at various times after delivery (2, 24, and 72 h) or a placebo (whey). In our randomized, double-blind placebo-controlled (DBPC) trial, 31 healthy athletes were divided into four groups and assessed at baseline and after the intervention. <i>Results:</i> The trial revealed that only colostrum collected after 2 h and 24 h caused a significant reduction of intestinal permeability. The comparison of post-intervention vs. baseline Δ values produced statistically significant results for 2 h colostrum versus the placebo and 72 h colostrum groups. <i>Conclusions:</i> We conclude that the change of bovine colostrum composition over the first three days of lactation is accompanied by a decrease in its biological activity as measured with the L/M test. This test may offer a biological quality measure for colostrum.https://www.mdpi.com/1010-660X/56/10/495bovine colostrum qualitybiological activitybioactive componentsintestinal permeabilitylactulose/mannitol absorption test |
| spellingShingle | Maciej Hałasa Dominika Maciejewska-Markiewicz Magdalena Baśkiewicz-Hałasa Krzysztof Safranow Ewa Stachowska Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test Medicina bovine colostrum quality biological activity bioactive components intestinal permeability lactulose/mannitol absorption test |
| title | Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test |
| title_full | Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test |
| title_fullStr | Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test |
| title_full_unstemmed | Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test |
| title_short | Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test |
| title_sort | post delivery milking delay influence on the effect of oral supplementation with bovine colostrum as measured with intestinal permeability test |
| topic | bovine colostrum quality biological activity bioactive components intestinal permeability lactulose/mannitol absorption test |
| url | https://www.mdpi.com/1010-660X/56/10/495 |
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