Blocking the PD-1/PD-L1 axis enhanced cisplatin chemotherapy in osteosarcoma in vitro and in vivo

Blocking the PD-1/PD-L1 axis enhanced cisplatin chemotherapy in osteosarcoma in vitro and in vivo

Abstract Background The blocking of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis has been found to have an anticancer activity against various types of cancer by enhancing T cell immunity, while there are no studies linking the PD-1/PD-L1 axis to chemotherapy drugs...

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Bibliographic Details
Main Authors: Xiaoqiang Liu, Shaoya He, Huaming Wu, Hui Xie, Tao Zhang, Zhongliang Deng
Format: Article
Language:English
Published: Komiyama Printing Co. Ltd 2019-12-01
Series:Environmental Health and Preventive Medicine
Subjects:
Osteosarcoma
PD-L1
Cisplatin
Anti-PD-1 antibody
Treg cell
Online Access:https://doi.org/10.1186/s12199-019-0835-3

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