Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties
The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the <i>Pseudomonas</i> and <i>Burkholderia</i> genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of this cl...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5689 |
| _version_ | 1797545950273601536 |
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| author | Muhammad Saalim Jessica Villegas-Moreno Benjamin R. Clark |
| author_facet | Muhammad Saalim Jessica Villegas-Moreno Benjamin R. Clark |
| author_sort | Muhammad Saalim |
| collection | DOAJ |
| description | The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the <i>Pseudomonas</i> and <i>Burkholderia</i> genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of this class of compounds dates back to the 1940s, when a range of alkylquinolones with notable antibiotic properties were first isolated from <i>Pseudomonas aeruginosa</i>. More recently, it was discovered that an alkylquinolone derivative, the Pseudomonas Quinolone Signal (PQS) plays a key role in bacterial communication and quorum sensing in <i>Pseudomonas aeruginosa</i>. Many of the best-studied examples contain simple hydrocarbon side-chains, but more recent studies have revealed a wide range of structurally diverse examples from multiple bacterial genera, including those with aromatic, isoprenoid, or sulfur-containing side-chains. In addition to their well-known antimicrobial properties, alkylquinolones have been reported with antimalarial, antifungal, antialgal, and antioxidant properties. Here we review the structural diversity and biological activity of these intriguing metabolites. |
| first_indexed | 2024-03-10T14:22:16Z |
| format | Article |
| id | doaj.art-4eaa7721a3b44221822da4bbad766a46 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:22:16Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4eaa7721a3b44221822da4bbad766a462023-11-20T23:14:44ZengMDPI AGMolecules1420-30492020-12-012523568910.3390/molecules25235689Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological PropertiesMuhammad Saalim0Jessica Villegas-Moreno1Benjamin R. Clark2School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300092, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300092, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300092, ChinaThe alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the <i>Pseudomonas</i> and <i>Burkholderia</i> genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of this class of compounds dates back to the 1940s, when a range of alkylquinolones with notable antibiotic properties were first isolated from <i>Pseudomonas aeruginosa</i>. More recently, it was discovered that an alkylquinolone derivative, the Pseudomonas Quinolone Signal (PQS) plays a key role in bacterial communication and quorum sensing in <i>Pseudomonas aeruginosa</i>. Many of the best-studied examples contain simple hydrocarbon side-chains, but more recent studies have revealed a wide range of structurally diverse examples from multiple bacterial genera, including those with aromatic, isoprenoid, or sulfur-containing side-chains. In addition to their well-known antimicrobial properties, alkylquinolones have been reported with antimalarial, antifungal, antialgal, and antioxidant properties. Here we review the structural diversity and biological activity of these intriguing metabolites.https://www.mdpi.com/1420-3049/25/23/5689quinolonesquorum sensing<i>Pseudomonas aeruginosa</i> |
| spellingShingle | Muhammad Saalim Jessica Villegas-Moreno Benjamin R. Clark Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties Molecules quinolones quorum sensing <i>Pseudomonas aeruginosa</i> |
| title | Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties |
| title_full | Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties |
| title_fullStr | Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties |
| title_full_unstemmed | Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties |
| title_short | Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties |
| title_sort | bacterial alkyl 4 quinolones discovery structural diversity and biological properties |
| topic | quinolones quorum sensing <i>Pseudomonas aeruginosa</i> |
| url | https://www.mdpi.com/1420-3049/25/23/5689 |
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