Summary of animal models of myelodysplastic syndrome
Abstract Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12144 |
| _version_ | 1818642344690319360 |
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| author | Weisha Li Mengyuan Li Xingjiu Yang Wenlong Zhang Lin Cao Ran Gao |
| author_facet | Weisha Li Mengyuan Li Xingjiu Yang Wenlong Zhang Lin Cao Ran Gao |
| author_sort | Weisha Li |
| collection | DOAJ |
| description | Abstract Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS). |
| first_indexed | 2024-12-16T23:41:34Z |
| format | Article |
| id | doaj.art-4eaaa1bed1054c629467d34b9f86d066 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-12-16T23:41:34Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-4eaaa1bed1054c629467d34b9f86d0662022-12-21T22:11:36ZengWileyAnimal Models and Experimental Medicine2576-20952021-03-0141717610.1002/ame2.12144Summary of animal models of myelodysplastic syndromeWeisha Li0Mengyuan Li1Xingjiu Yang2Wenlong Zhang3Lin Cao4Ran Gao5NHC Key Laboratory of Human Disease Comparative Medicine Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Beijing ChinaBeijing Tongren Hospital Affiliated to Capital Medical University Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine Beijing ChinaAbstract Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).https://doi.org/10.1002/ame2.12144animal modelsLeukemiamyelodysplastic syndrome (MDS) |
| spellingShingle | Weisha Li Mengyuan Li Xingjiu Yang Wenlong Zhang Lin Cao Ran Gao Summary of animal models of myelodysplastic syndrome Animal Models and Experimental Medicine animal models Leukemia myelodysplastic syndrome (MDS) |
| title | Summary of animal models of myelodysplastic syndrome |
| title_full | Summary of animal models of myelodysplastic syndrome |
| title_fullStr | Summary of animal models of myelodysplastic syndrome |
| title_full_unstemmed | Summary of animal models of myelodysplastic syndrome |
| title_short | Summary of animal models of myelodysplastic syndrome |
| title_sort | summary of animal models of myelodysplastic syndrome |
| topic | animal models Leukemia myelodysplastic syndrome (MDS) |
| url | https://doi.org/10.1002/ame2.12144 |
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