Transplant in Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma is the most common type of aggressive lymphoma. Patients that don’t respond to first-line therapy have a poor prognosis. Bone marrow transplant represents an effective and established salvage treatment for those patients, with curative potential. Autologous transplant...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Transplante de Órgãos
2022-06-01
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| Series: | Brazilian Journal of Transplantation |
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| Online Access: | https://bjt.emnuvens.com.br/revista/article/view/445 |
| _version_ | 1828764026789691392 |
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| author | Guilherme Duffles Carmino De Souza |
| author_facet | Guilherme Duffles Carmino De Souza |
| author_sort | Guilherme Duffles |
| collection | DOAJ |
| description |
Diffuse large B-cell lymphoma is the most common type of aggressive lymphoma. Patients that don’t respond to first-line therapy have a poor prognosis. Bone marrow transplant represents an effective and established salvage treatment for those patients, with curative potential. Autologous transplant uses the patient stem cell for rescue after high-dose myeloablative chemotherapy, while allogenic transplant relies on a different stem cell for a graft-versus-lymphoma effect. With distinct toxicity and capacity to induce remission, those therapies have great value in the management of patients with relapsed and refractory diffuse large B-cell lymphoma.
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| first_indexed | 2024-12-11T02:12:00Z |
| format | Article |
| id | doaj.art-4ead3e8000d94b92b7ffcc9cd5558d87 |
| institution | Directory Open Access Journal |
| issn | 2764-1589 |
| language | English |
| last_indexed | 2024-12-11T02:12:00Z |
| publishDate | 2022-06-01 |
| publisher | Associação Brasileira de Transplante de Órgãos |
| record_format | Article |
| series | Brazilian Journal of Transplantation |
| spelling | doaj.art-4ead3e8000d94b92b7ffcc9cd5558d872022-12-22T01:24:15ZengAssociação Brasileira de Transplante de ÓrgãosBrazilian Journal of Transplantation2764-15892022-06-01252Transplant in Diffuse Large B-Cell LymphomaGuilherme Duffles0Carmino De Souza1Universidade Estadual de Campinas – Faculdade de Ciências Médicas – Hematology and Hemotherapy Center, Campinas (SP), Brazil.Universidade Estadual de Campinas – Faculdade de Ciências Médicas – Hematology and Hemotherapy Center, Campinas (SP), Brazil. Diffuse large B-cell lymphoma is the most common type of aggressive lymphoma. Patients that don’t respond to first-line therapy have a poor prognosis. Bone marrow transplant represents an effective and established salvage treatment for those patients, with curative potential. Autologous transplant uses the patient stem cell for rescue after high-dose myeloablative chemotherapy, while allogenic transplant relies on a different stem cell for a graft-versus-lymphoma effect. With distinct toxicity and capacity to induce remission, those therapies have great value in the management of patients with relapsed and refractory diffuse large B-cell lymphoma. https://bjt.emnuvens.com.br/revista/article/view/445LynphomaTransplantation, AutologousTransplantation, Allogenic |
| spellingShingle | Guilherme Duffles Carmino De Souza Transplant in Diffuse Large B-Cell Lymphoma Brazilian Journal of Transplantation Lynphoma Transplantation, Autologous Transplantation, Allogenic |
| title | Transplant in Diffuse Large B-Cell Lymphoma |
| title_full | Transplant in Diffuse Large B-Cell Lymphoma |
| title_fullStr | Transplant in Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | Transplant in Diffuse Large B-Cell Lymphoma |
| title_short | Transplant in Diffuse Large B-Cell Lymphoma |
| title_sort | transplant in diffuse large b cell lymphoma |
| topic | Lynphoma Transplantation, Autologous Transplantation, Allogenic |
| url | https://bjt.emnuvens.com.br/revista/article/view/445 |
| work_keys_str_mv | AT guilhermeduffles transplantindiffuselargebcelllymphoma AT carminodesouza transplantindiffuselargebcelllymphoma |