Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum
Tapia-Alveal, Olsen and Worgall develop a novel strategy for patient-specific multiple myeloma diagnostics platform using DNA aptamers. The high affinity DNA aptamers enabled detection of minimal residual disease (MRD) when conventional MRD methods assessed complete remission and are adaptable to mu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-020-01515-x |
| _version_ | 1818842958249590784 |
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| author | Claudia Tapia-Alveal Timothy R. Olsen Tilla S. Worgall |
| author_facet | Claudia Tapia-Alveal Timothy R. Olsen Tilla S. Worgall |
| author_sort | Claudia Tapia-Alveal |
| collection | DOAJ |
| description | Tapia-Alveal, Olsen and Worgall develop a novel strategy for patient-specific multiple myeloma diagnostics platform using DNA aptamers. The high affinity DNA aptamers enabled detection of minimal residual disease (MRD) when conventional MRD methods assessed complete remission and are adaptable to multiple diagnostic formats including point-of-care devices. |
| first_indexed | 2024-12-19T04:50:14Z |
| format | Article |
| id | doaj.art-4eae892611494e1689d790423c725031 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T04:50:14Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-4eae892611494e1689d790423c7250312022-12-21T20:35:22ZengNature PortfolioCommunications Biology2399-36422020-12-013111210.1038/s42003-020-01515-xPersonalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serumClaudia Tapia-Alveal0Timothy R. Olsen1Tilla S. Worgall2Department of Pathology and Cell Biology, Columbia University Irving Medical CenterDepartment of Pathology and Cell Biology, Columbia University Irving Medical CenterDepartment of Pathology and Cell Biology, Columbia University Irving Medical CenterTapia-Alveal, Olsen and Worgall develop a novel strategy for patient-specific multiple myeloma diagnostics platform using DNA aptamers. The high affinity DNA aptamers enabled detection of minimal residual disease (MRD) when conventional MRD methods assessed complete remission and are adaptable to multiple diagnostic formats including point-of-care devices.https://doi.org/10.1038/s42003-020-01515-x |
| spellingShingle | Claudia Tapia-Alveal Timothy R. Olsen Tilla S. Worgall Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum Communications Biology |
| title | Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| title_full | Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| title_fullStr | Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| title_full_unstemmed | Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| title_short | Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| title_sort | personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum |
| url | https://doi.org/10.1038/s42003-020-01515-x |
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