<i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
<i>Neisseria meningitidis</i>-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs refl...
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MDPI AG
2020-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/3/171 |
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| author | Meng-Yu Wu Chien-Sheng Chen Chih-Yi Tsay Giou-Teng Yiang Jian-Yu Ke Po-Chen Lin |
| author_facet | Meng-Yu Wu Chien-Sheng Chen Chih-Yi Tsay Giou-Teng Yiang Jian-Yu Ke Po-Chen Lin |
| author_sort | Meng-Yu Wu |
| collection | DOAJ |
| description | <i>Neisseria meningitidis</i>-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse−Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant <i>Neisseria meningitidis-</i>induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC and multiple organ failure was noted. WFS was chiefly suspected. We highlight the clinical features and pathogenesis of <i>Neisseria meningitidis</i>-induced meningococcemia and WFS. We propose that they should be kept in mind, especially in patients presenting with a petechial eruption and purpura fulminans. |
| first_indexed | 2024-12-19T23:01:41Z |
| format | Article |
| id | doaj.art-4eaf37afd8fa424ab0e75e258101f053 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-19T23:01:41Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4eaf37afd8fa424ab0e75e258101f0532022-12-21T20:02:29ZengMDPI AGBrain Sciences2076-34252020-03-0110317110.3390/brainsci10030171brainsci10030171<i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ FailureMeng-Yu Wu0Chien-Sheng Chen1Chih-Yi Tsay2Giou-Teng Yiang3Jian-Yu Ke4Po-Chen Lin5Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan<i>Neisseria meningitidis</i>-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse−Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant <i>Neisseria meningitidis-</i>induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC and multiple organ failure was noted. WFS was chiefly suspected. We highlight the clinical features and pathogenesis of <i>Neisseria meningitidis</i>-induced meningococcemia and WFS. We propose that they should be kept in mind, especially in patients presenting with a petechial eruption and purpura fulminans.https://www.mdpi.com/2076-3425/10/3/171<i>neisseria meningitidis</i>meningococcemiawaterhouse–friderichsen syndromedisseminated intravascular coagulationmultiple organ failure |
| spellingShingle | Meng-Yu Wu Chien-Sheng Chen Chih-Yi Tsay Giou-Teng Yiang Jian-Yu Ke Po-Chen Lin <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure Brain Sciences <i>neisseria meningitidis</i> meningococcemia waterhouse–friderichsen syndrome disseminated intravascular coagulation multiple organ failure |
| title | <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure |
| title_full | <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure |
| title_fullStr | <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure |
| title_full_unstemmed | <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure |
| title_short | <i>Neisseria meningitidis</i> Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure |
| title_sort | i neisseria meningitidis i induced fatal waterhouse friderichsen syndrome in a patient presenting with disseminated intravascular coagulation and multiple organ failure |
| topic | <i>neisseria meningitidis</i> meningococcemia waterhouse–friderichsen syndrome disseminated intravascular coagulation multiple organ failure |
| url | https://www.mdpi.com/2076-3425/10/3/171 |
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