| Summary: | This correlation study aimed to assess global trends of lip and oral cavity (LOC) cancer mortality due to chewing tobacco in the period 1990–2019. Among women, the highest proportion of deaths by LOC cancer attributed to chewing tobacco was 27.7% in 2019, with a positive correlation between mortality of LOC cancer and chewing tobacco in the studied period (r = +0.832, <i>p</i> < 0.001). Among men, the contribution of chewing tobacco to LOC cancer burden globally was 14.1% in 2019, with a negative correlation between mortality of LOC cancer in males and chewing tobacco (r = −0.564, <i>p</i> < 0.01). The percentage of deaths for LOC cancer attributable to chewing tobacco is concentrated in certain world regions (mainly in South East Asia and Eastern Mediterranean), with significantly increasing trends.
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