Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression

Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression

Abstract The preferred method for disease modeling using induced pluripotent stem cells (iPSCs) is to generate isogenic cell lines by correcting or introducing pathogenic mutations. Base editing enables the precise installation of point mutations at specific genomic locations without the need for de...

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Bibliographic Details
Main Authors: Krittika Nandy, Dinesh Babu, Sonam Rani, Gaurav Joshi, Smitha Ijee, Anila George, Dhavapriya Palani, Chitra Premkumar, Praveena Rajesh, S. Vijayanand, Ernest David, Mohankumar Murugesan, Shaji R. Velayudhan
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42174-2

Internet

https://doi.org/10.1038/s41598-023-42174-2

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