Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

Anti-apoptotic BCL-2 family members bind to BH3-only proteins and multidomain BAX/BAK to preserve mitochondrial integrity and maintain survival. Whereas inhibition of these interactions is the biological basis of BH3-mimetic anti-cancer therapy, the actual response of membrane-bound protein complexe...

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Bibliographic Details
Main Authors: Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A. Sarosiek, Florian J. Bock, Frédérique Braun, Anthony Letai, Stephen W.G. Tait, Fabien Gautier, Philippe P. Juin
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
BCL-xL
membrane localization
BH3 mimetic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316382

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