Association of serum prolactin levels and thyroid hormones with poisoned patient outcome
Background: In acute and chronic phases of severe diseases, endocrine changes occur. Some hormones, such as prolactin (PRL) and thyroid hormones, were considered predictors of ICU patients' outcomes. The present study evaluates thyroid hormone profile, serum PRL level, and their relationship wi...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-09-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
| Subjects: | |
| Online Access: | https://apjmt.mums.ac.ir/article_18728_63875311bdc78c8b7f60b2ddc641790e.pdf |
| _version_ | 1818567242001940480 |
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| author | Arezou Mahdavinejad Peyman Erfan Talab evini Mitra Rahimi Shahin Shadnia |
| author_facet | Arezou Mahdavinejad Peyman Erfan Talab evini Mitra Rahimi Shahin Shadnia |
| author_sort | Arezou Mahdavinejad |
| collection | DOAJ |
| description | Background: In acute and chronic phases of severe diseases, endocrine changes occur. Some hormones, such as prolactin (PRL) and thyroid hormones, were considered predictors of ICU patients' outcomes. The present study evaluates thyroid hormone profile, serum PRL level, and their relationship with ICU poisoned patients' mortality rate.Methods: This study included 140 inpatients in the Toxicology Intensive Care Unit (TICU) who enrolled in a prospective study of a single center and observational. After admission to the ICU, the researchers collected venous blood samples from all patients directly. Concurrently, the APACHE II score was calculated. The collected samples analysis was performed based on the entire triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and PRL level.Results: One hundred and forty subjects were studied, of which 109 (75.85%) were male with a mean age of 34.17 ± 14.01. One hundred and eighteen patients were survivors with a mean age of 33.29 ±13.76. In contrast, 22 patients with a mean age of 38.91 ±14.69 died. The model of PRL combined with APACHE II score (OR 1.17, 95% CI 1.06 to 1.28, P-value =0.001) was the best model for predicting post-ICU mortality in our study.Conclusions: This study’s results are consistent with the previous research, indicating a higher incidence of thyroid and PRL hormone changes in patients hospitalized in the ICU. It can be concluded that the presence of PRL based on the APACHE II score can lead us to be more precise in predicting the outcome of poisoning in hospitalized patients. |
| first_indexed | 2024-12-14T06:20:55Z |
| format | Article |
| id | doaj.art-4eb48cbb210b45d48b43e4cc353b474f |
| institution | Directory Open Access Journal |
| issn | 2322-2611 2322-4320 |
| language | English |
| last_indexed | 2024-12-14T06:20:55Z |
| publishDate | 2021-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj.art-4eb48cbb210b45d48b43e4cc353b474f2022-12-21T23:13:50ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202021-09-0110310210610.22038/apjmt.2021.1872818728Association of serum prolactin levels and thyroid hormones with poisoned patient outcomeArezou Mahdavinejad0Peyman Erfan Talab evini1Mitra Rahimi2Shahin Shadnia3Toxicology Research Center, Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranToxicology Research Center, Excellence Center of Clinical Toxicology AND Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranShahid Beheshti University of Medical SciencesToxicology Research Center, Excellence Center of Clinical Toxicology AND Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: In acute and chronic phases of severe diseases, endocrine changes occur. Some hormones, such as prolactin (PRL) and thyroid hormones, were considered predictors of ICU patients' outcomes. The present study evaluates thyroid hormone profile, serum PRL level, and their relationship with ICU poisoned patients' mortality rate.Methods: This study included 140 inpatients in the Toxicology Intensive Care Unit (TICU) who enrolled in a prospective study of a single center and observational. After admission to the ICU, the researchers collected venous blood samples from all patients directly. Concurrently, the APACHE II score was calculated. The collected samples analysis was performed based on the entire triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and PRL level.Results: One hundred and forty subjects were studied, of which 109 (75.85%) were male with a mean age of 34.17 ± 14.01. One hundred and eighteen patients were survivors with a mean age of 33.29 ±13.76. In contrast, 22 patients with a mean age of 38.91 ±14.69 died. The model of PRL combined with APACHE II score (OR 1.17, 95% CI 1.06 to 1.28, P-value =0.001) was the best model for predicting post-ICU mortality in our study.Conclusions: This study’s results are consistent with the previous research, indicating a higher incidence of thyroid and PRL hormone changes in patients hospitalized in the ICU. It can be concluded that the presence of PRL based on the APACHE II score can lead us to be more precise in predicting the outcome of poisoning in hospitalized patients.https://apjmt.mums.ac.ir/article_18728_63875311bdc78c8b7f60b2ddc641790e.pdfapache ii scoremortalityprolactinthyroid hormones |
| spellingShingle | Arezou Mahdavinejad Peyman Erfan Talab evini Mitra Rahimi Shahin Shadnia Association of serum prolactin levels and thyroid hormones with poisoned patient outcome Asia Pacific Journal of Medical Toxicology apache ii score mortality prolactin thyroid hormones |
| title | Association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| title_full | Association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| title_fullStr | Association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| title_full_unstemmed | Association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| title_short | Association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| title_sort | association of serum prolactin levels and thyroid hormones with poisoned patient outcome |
| topic | apache ii score mortality prolactin thyroid hormones |
| url | https://apjmt.mums.ac.ir/article_18728_63875311bdc78c8b7f60b2ddc641790e.pdf |
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