| Summary: | <i>Background and objectives</i>: Oral moisturizers have been used to treat dry mouth. This study aimed to investigate the effects of storage temperature and pH on the antifungal effects of oral moisturizers against <i>Candida albicans</i> and <i>Candida glabrata</i>. <i>Materials and Methods</i>: Thirty-one oral moisturizers and amphotericin B (AMPH-B) were stored at 25 and 37 °C for 1 week. Subsequently, they were added to cylindrical holes in 50% trypticase soy agar plates inoculated with <i>C. albicans</i> and <i>C. glabrata</i> (10<sup>7</sup> cells/ml). The antifungal effects were evaluated based on the sizes of the growth-inhibitory zones formed. Two-way analysis of variance was used to determine the effects of storage temperature and pH on the growth-inhibitory zones. <i>Results</i>: Significant differences in the effects of storage temperature and pH of the moisturizers were observed against <i>C. albicans</i> and <i>C. glabrata</i>. The growth-inhibitory zones of samples stored at 37 °C and with neutral pH were significantly larger than those stored at 25 °C and with acidic pH, respectively. The sizes of the zones formed by most of the oral moisturizers were larger than those formed by AMPH-B (concentration, 0.63 µg/ml). <i>Conclusion</i>: The antifungal effects of oral moisturizers against <i>C. albicans</i> and <i>C. glabrata</i> were affected by their storage temperature and pH.
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