Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis
Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate athe...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/811 |
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| author | Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu |
| author_facet | Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties. Although there is a shortage of direct clinical evidence demonstrating the benefits of melatonin in CAS patients, previous studies have shown that melatonin may be beneficial for patients with CAS in terms of reducing endothelial damage, stabilizing arterial plaque, mitigating the harm from CAS-related ischemic stroke and cerebral I/R injury, and alleviating the adverse effects of the related risk factors. Additional pre-clinical and clinical are required to confirm this speculation. |
| first_indexed | 2024-03-09T05:41:04Z |
| format | Article |
| id | doaj.art-4eb5876d4e784303905c2435b68708e4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:41:04Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4eb5876d4e784303905c2435b68708e42023-12-03T12:24:51ZengMDPI AGMolecules1420-30492021-02-0126481110.3390/molecules26040811Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial StenosisRui Zhang0Leng Ni1Xiao Di2Baitao Ma3Shuai Niu4Zhihua Rong5Changwei Liu6Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaCarotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties. Although there is a shortage of direct clinical evidence demonstrating the benefits of melatonin in CAS patients, previous studies have shown that melatonin may be beneficial for patients with CAS in terms of reducing endothelial damage, stabilizing arterial plaque, mitigating the harm from CAS-related ischemic stroke and cerebral I/R injury, and alleviating the adverse effects of the related risk factors. Additional pre-clinical and clinical are required to confirm this speculation.https://www.mdpi.com/1420-3049/26/4/811melatonincarotid artery stenosisischemic strokeatherosclerosis |
| spellingShingle | Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis Molecules melatonin carotid artery stenosis ischemic stroke atherosclerosis |
| title | Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis |
| title_full | Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis |
| title_fullStr | Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis |
| title_full_unstemmed | Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis |
| title_short | Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis |
| title_sort | potential role of melatonin as an adjuvant for atherosclerotic carotid arterial stenosis |
| topic | melatonin carotid artery stenosis ischemic stroke atherosclerosis |
| url | https://www.mdpi.com/1420-3049/26/4/811 |
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