Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

Introduction: Meteorin-like hormone (Metrnl) is ubiquitously expressed in skeletal muscle, heart, and adipose with beneficial roles in obesity, insulin resistance, and inflammation. Metrnl is found to protect against cardiac hypertrophy and doxorubicin-induced cardiotoxicity. However, its role in di...

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Bibliographic Details
Main Authors: Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai-Ming Niu, Ke-Xue Li, Ji-Ru Zhang, Hai-Jian Sun
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Advanced Research
Subjects:
Diabetes
Cardiomyopathy
Metrnl
AMPK
Autophagy
STING
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222002430

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