Coronary artery disease in a patient with Addison’s disease: a case report and literature review
Abstract Background Addison’s disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison’s disease may accelerate progression of co-existed c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03079-0 |
| _version_ | 1811176014197293056 |
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| author | Ruohan Zhao Suxin Luo Shuzhen Wang Yi Wen Feng Xiong |
| author_facet | Ruohan Zhao Suxin Luo Shuzhen Wang Yi Wen Feng Xiong |
| author_sort | Ruohan Zhao |
| collection | DOAJ |
| description | Abstract Background Addison’s disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison’s disease may accelerate progression of co-existed cardiovascular diseases. Addison’s disease combined with cardiovascular disease is infrequent, only 10 cases in the literature. Case presentation We reported a 51-year-old male patient with unstable angina pectoris and hypotension. Changes on coronary angiography within 2 years suggested rapid progression of coronary artery disease in a patient with low cardiovascular risk. An additional clue of skin hyperpigmentation, fatigue and further examination confirmed the diagnosis of Addison’s disease caused by adrenal tuberculosis. After hormone replacement treatment, the frequency and severity of the angina pectoris were alleviated significantly, as were hypotension, hyperpigmentation and fatigue. Conclusions The combination of Addison’s disease and coronary artery disease in one patient is rare. Addison’s disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison’s disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly. |
| first_indexed | 2024-04-10T19:45:07Z |
| format | Article |
| id | doaj.art-4eb8ed72f0924f2f91c3c887a7447e5c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-10T19:45:07Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4eb8ed72f0924f2f91c3c887a7447e5c2023-01-29T12:03:51ZengBMCBMC Cardiovascular Disorders1471-22612023-01-012311910.1186/s12872-023-03079-0Coronary artery disease in a patient with Addison’s disease: a case report and literature reviewRuohan Zhao0Suxin Luo1Shuzhen Wang2Yi Wen3Feng Xiong4Department of Cardiology, Cardiovascular Institute of Chengdu Third People’s Hospital/The Affiliated Hospital of Southwest Jiaotong UniversityDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, Cardiovascular Institute of Chengdu Third People’s Hospital/The Affiliated Hospital of Southwest Jiaotong UniversityHealth Management Centre, University-Town Hospital of Chongqing Medical UniversityDepartment of Cardiology, Cardiovascular Institute of Chengdu Third People’s Hospital/The Affiliated Hospital of Southwest Jiaotong UniversityAbstract Background Addison’s disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison’s disease may accelerate progression of co-existed cardiovascular diseases. Addison’s disease combined with cardiovascular disease is infrequent, only 10 cases in the literature. Case presentation We reported a 51-year-old male patient with unstable angina pectoris and hypotension. Changes on coronary angiography within 2 years suggested rapid progression of coronary artery disease in a patient with low cardiovascular risk. An additional clue of skin hyperpigmentation, fatigue and further examination confirmed the diagnosis of Addison’s disease caused by adrenal tuberculosis. After hormone replacement treatment, the frequency and severity of the angina pectoris were alleviated significantly, as were hypotension, hyperpigmentation and fatigue. Conclusions The combination of Addison’s disease and coronary artery disease in one patient is rare. Addison’s disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison’s disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly.https://doi.org/10.1186/s12872-023-03079-0Addison’s diseaseAdrenal tuberculosisUnstable anginaCoronary artery diseaseCase report |
| spellingShingle | Ruohan Zhao Suxin Luo Shuzhen Wang Yi Wen Feng Xiong Coronary artery disease in a patient with Addison’s disease: a case report and literature review BMC Cardiovascular Disorders Addison’s disease Adrenal tuberculosis Unstable angina Coronary artery disease Case report |
| title | Coronary artery disease in a patient with Addison’s disease: a case report and literature review |
| title_full | Coronary artery disease in a patient with Addison’s disease: a case report and literature review |
| title_fullStr | Coronary artery disease in a patient with Addison’s disease: a case report and literature review |
| title_full_unstemmed | Coronary artery disease in a patient with Addison’s disease: a case report and literature review |
| title_short | Coronary artery disease in a patient with Addison’s disease: a case report and literature review |
| title_sort | coronary artery disease in a patient with addison s disease a case report and literature review |
| topic | Addison’s disease Adrenal tuberculosis Unstable angina Coronary artery disease Case report |
| url | https://doi.org/10.1186/s12872-023-03079-0 |
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