Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is used to perform perfusion imaging without administration of contrast media. However, the reliability of ASL for musculoskeletal tumors and the influence of post-labeling delay (PLD) have not been fully clarified. This study aimed to ev...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2450 |
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| author | Chien-Hung Lin Tsyh-Jyi Hsieh Yi-Chen Chou Clement Kuen-Huang Chen |
| author_facet | Chien-Hung Lin Tsyh-Jyi Hsieh Yi-Chen Chou Clement Kuen-Huang Chen |
| author_sort | Chien-Hung Lin |
| collection | DOAJ |
| description | Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is used to perform perfusion imaging without administration of contrast media. However, the reliability of ASL for musculoskeletal tumors and the influence of post-labeling delay (PLD) have not been fully clarified. This study aimed to evaluate the performance of ASL with different PLDs in the imaging of musculoskeletal tumors. Forty-five patients were enrolled and were divided into a malignant group, a hypervascular benign group, a hypovascular benign group and a control group. The tissue blood flow (TBF) of the lesions and normal muscles was measured and the lesion-to-muscle TBF ratio and differences were calculated. The results showed that both the TBF of lesions and muscles increased as the PLD increased, and the TBF of muscles correlated significantly and positively with the TBF of lesions (all <i>p</i> < 0.05). The TBF and lesion-to-muscle TBF differences of the malignant lesions were significantly higher than those of the hypovascular benign lesions and the control group in all PLD groups (all <i>p</i> < 0.0125) and only those of the hypervascular benign lesions in the longest PLD (3025 ms) group (<i>p</i> = 0.0120, 0.0116). In conclusion, ASL detects high TBF in malignant tumors and hypervascular benign lesions, and a longer PLD is recommended for ASL to differentiate musculoskeletal tumors. |
| first_indexed | 2024-03-09T20:22:15Z |
| format | Article |
| id | doaj.art-4eb9b0a91e88452cadb236111c428f3d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:22:15Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4eb9b0a91e88452cadb236111c428f3d2023-11-23T23:45:31ZengMDPI AGDiagnostics2075-44182022-10-011210245010.3390/diagnostics12102450Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling DelayChien-Hung Lin0Tsyh-Jyi Hsieh1Yi-Chen Chou2Clement Kuen-Huang Chen3Department of Medical Imaging, Chi Mei Medical Center, Yongkang, Tainan 71004, TaiwanDepartment of Medical Imaging, Chi Mei Medical Center, Yongkang, Tainan 71004, TaiwanDepartment of Medical Imaging, Chi Mei Medical Center, Yongkang, Tainan 71004, TaiwanDepartment of Medical Imaging, Chi Mei Medical Center, Yongkang, Tainan 71004, TaiwanArterial spin labeling (ASL) magnetic resonance imaging (MRI) is used to perform perfusion imaging without administration of contrast media. However, the reliability of ASL for musculoskeletal tumors and the influence of post-labeling delay (PLD) have not been fully clarified. This study aimed to evaluate the performance of ASL with different PLDs in the imaging of musculoskeletal tumors. Forty-five patients were enrolled and were divided into a malignant group, a hypervascular benign group, a hypovascular benign group and a control group. The tissue blood flow (TBF) of the lesions and normal muscles was measured and the lesion-to-muscle TBF ratio and differences were calculated. The results showed that both the TBF of lesions and muscles increased as the PLD increased, and the TBF of muscles correlated significantly and positively with the TBF of lesions (all <i>p</i> < 0.05). The TBF and lesion-to-muscle TBF differences of the malignant lesions were significantly higher than those of the hypovascular benign lesions and the control group in all PLD groups (all <i>p</i> < 0.0125) and only those of the hypervascular benign lesions in the longest PLD (3025 ms) group (<i>p</i> = 0.0120, 0.0116). In conclusion, ASL detects high TBF in malignant tumors and hypervascular benign lesions, and a longer PLD is recommended for ASL to differentiate musculoskeletal tumors.https://www.mdpi.com/2075-4418/12/10/2450arterial spin labelingmagnetic resonance imaging (MRI)musculoskeletal tumortissue perfusiontumor vascularity |
| spellingShingle | Chien-Hung Lin Tsyh-Jyi Hsieh Yi-Chen Chou Clement Kuen-Huang Chen Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay Diagnostics arterial spin labeling magnetic resonance imaging (MRI) musculoskeletal tumor tissue perfusion tumor vascularity |
| title | Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay |
| title_full | Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay |
| title_fullStr | Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay |
| title_full_unstemmed | Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay |
| title_short | Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay |
| title_sort | feasibility of arterial spin labeling magnetic resonance imaging for musculoskeletal tumors with optimized post labeling delay |
| topic | arterial spin labeling magnetic resonance imaging (MRI) musculoskeletal tumor tissue perfusion tumor vascularity |
| url | https://www.mdpi.com/2075-4418/12/10/2450 |
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