Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated in the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy). However, the mechanism by which NLRP3 inflammasome products are released from p...

Description complète

Détails bibliographiques
Auteurs principaux:	Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li
Format:	Article
Langue:	English
Publié:	Elsevier 2021-07-01
Collection:	Redox Biology
Sujets:	Podocyte Homocysteine Reactive oxygen species TRPML1 channel Exosome Lysosome
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213231721001713

Documents similaires

TRPML1—Emerging Roles in Cancer
par: Yiming Yang, et autres
Publié: (2020-12-01)

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
par: Eva Plesch, et autres
Publié: (2018-11-01)

Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach
par: Boyun Kim, et autres
Publié: (2024-01-01)

Modulation of Lysosomal Cl<sup>−</sup> Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl<sup>−</sup> Sensor
par: Dongun Lee, et autres
Publié: (2023-07-01)

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity
par: Jingjing Zhang, et autres
Publié: (2023-01-01)

Zinc oxide nanoparticles trigger autophagy-mediated cell death through activating lysosomal TRPML1 in normal kidney cells
par: Boyun Kim, et autres
Publié: (2023-01-01)

ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice
par: Heng Liu, et autres
Publié: (2024-12-01)

Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells
par: Valentina Brunetti, et autres
Publié: (2024-06-01)

Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub
par: Guangbi Li, et autres
Publié: (2015-03-01)

Effect of Sirt1 on high glucose-induced exosome release from podocytes
par: DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
Publié: (2024-02-01)

TRPML1 gating modulation by allosteric mutations and lipids
par: Ninghai Gan, et autres
Publié: (2024-10-01)

Lysosomal Ca2+ release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons
par: Qian Lei, et autres
Publié: (2024-10-01)

Aza Analogs of the TRPML1 Inhibitor Estradiol Methyl Ether (EDME)
par: Philipp Rühl, et autres
Publié: (2023-11-01)

Research progress on exosomes in podocyte injury associated with diabetic kidney disease
par: Jiao Li, et autres
Publié: (2023-03-01)

The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment
par: Giorgio Santoni, et autres
Publié: (2022-01-01)

Podocyte Pathology and Nephropathy
par: Barbara eLewko, et autres
Publié: (2015-09-01)

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma
par: Wanlu Du, et autres
Publié: (2021-10-01)

Exosomes secreted by podocytes regulate the differentiation of Th17/Treg cells in idiopathic nephrotic syndrome
par: Yang Jia, et autres
Publié: (2024-09-01)

Endolysosomal transient receptor potential mucolipins and two-pore channels: implications for cancer immunity
par: Lina Ouologuem, et autres
Publié: (2024-05-01)

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
par: Sensen Zhang, et autres
Publié: (2017-09-01)

TRPML1 as a potential therapeutic target for triple-negative breast cancer: a review
par: Ying Pan, et autres
Publié: (2023-12-01)

Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes
par: Maike R. Pollmanns, et autres
Publié: (2022-07-01)

Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
par: Xinyi Cheng, et autres
Publié: (2023-06-01)

Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
par: Carla Abrahamian, et autres
Publié: (2021-07-01)

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy
par: Mariana I. Capurro, et autres
Publié: (2023-12-01)

TRPML1 Participates in the Progression of Alzheimer’s Disease by Regulating the PPARγ/AMPK/Mtor Signalling Pathway
par: Lu Zhang, et autres
Publié: (2017-10-01)

Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV
par: Molly Mepyans, et autres
Publié: (2020-07-01)

Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1 lysosomal channel
par: Valentina Tedeschi, et autres
Publié: (2024-12-01)

Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
par: Giorgio Santoni, et autres
Publié: (2020-03-01)

Endolysosomal Cation Channels and Lung Disease
par: Barbara Spix, et autres
Publié: (2022-01-01)

Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
par: Sandra Prat Castro, et autres
Publié: (2022-09-01)

Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy
par: Luca eMusante, et autres
Publié: (2014-09-01)

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction
par: Leonardo Ermini, et autres
Publié: (2021-05-01)

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte
par: Juan Jin, et autres
Publié: (2019-03-01)

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
par: Li Lin, et autres
Publié: (2023-11-01)

Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus
par: Jian Lu, et autres
Publié: (2019-08-01)

Cyclosporine A Protects Podocytes by Regulating Transgelin in Adriamycin-Induced Podocyte Injury
par: Xiaoyan Li, et autres
Publié: (2024-07-01)

Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway
par: Ting Liu, et autres
Publié: (2018-02-01)

The Physiopathologic Roles of Calcium Signaling in Podocytes
par: Yu-Chi Tu, et autres
Publié: (2023-10-01)

A blood-brain barrier-penetrant AAV gene therapy improves neurological function in symptomatic mucolipidosis IV mice
par: Madison L. Sangster, et autres
Publié: (2024-06-01)