Neuropathological and Behavioral Consequences of Adeno-Associated Viral Vector-Mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats

Neuropathological and Behavioral Consequences of Adeno-Associated Viral Vector-Mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were continuously delivered to the striatum at biologically active levels via recombinant adeno-associated viral (rAAV) gene transfer 4–5 weeks prior to 30 min of middle cerebral artery occlusion (MCAO). The magnitude of the defi...

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Bibliographic Details
Main Authors: Gunnar Andsberg, Zaal Kokaia, Ronald L. Klein, Nicholas Muzyczka, Olle Lindvall, Ronald J. Mandel
Format: Article
Language:English
Published: Elsevier 2002-03-01
Series:Neurobiology of Disease
Subjects:
nerve growth factors
viral vector
stroke
ischemia
behavior
striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904565

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